Development and Validation of Simple UV-Spectrophotometric Method of Quantization of Domperidone in Solid Dosage Formulation using Mixed Solvency Concept

Abstract

Organic solvents are most frequently employed in spectrophotometric analyses. They may be the sources of pollution. Some of them may be toxic, while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Domperidone by the use of mixed solvency concept. Domperidone shows maximum absorbance in the concentrations range of 10–50µg/ml at 287 nm. Method of analyses had been validated for different parameters like linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ). The analytical method was found to be simple, safe (free from toxicity), economic and eco-friendly.

Keywords: Domperidone, UV-Spectrophotometry, solid dosage formulation, mixed solvency concept

Sanjay Jain,R.K. Maheshwari, Rajesh Kumar Nemaet al. Development and Validation of Simple UV-Spectrophotometric Method of Quantization of Domperidone in Solid Dosage Formulation using Mixed Solvency Concept. Research & Reviews: A Journal of Drug Design & Discovery. 2017; 4(2): 19–23p.