Study of Anti-Leishmanial Activities of Metabolites on Leishmania major: A Structure-Based Drug Designing Approach

Abstract

Cutaneous Leishmaniasis is one of the major problem all over the world and has no suitable treatment to treat this disease. However, the range of drugs is limited and increased use of these drugs lead to multiple drug resistance and has posed a major concern. Here the genome sequences of Leishmania major (responsible for cutaneous Leishmaniasis) is identified for having few drug targets that are unique to these parasites. GPI 8 protein is the protein target which makes it virulent inside the host.  Here we will do the homology modeling and molecular docking of the identified ligand with the L. major target protein (GPI 8) model using different software. This will help in further drug designing for cutaneous leishmaniasis.

Keywords: Cutaneous Leishmaniasis, drug discovery, lipophosphoglycan (LPG), Homology modeling

Cite this Article

Jaya Chakraborty, Shubha Dixit. Study of Anti-Leishmanial Activities of Metabolites on Leishmania major: A Structure-Based Drug Designing Approach. Research & Reviews: A Journal of Drug Design & Discovery. 2017; 4(3): 30–40p.