Formulation and Evaluation of Solid Lipid Nanoparticles of BCS Class II Drug

Abstract

In the present study, we explored the potential of antihypertensive drug loaded solid lipid nanoparticles (SLNs), as a new formulation in improving the oral bioavailability of drug, which otherwise reported with poor bioavailability. The problem of poor water-solubility has remained as a significant challenge in pharmaceutical industry. The reduction of drug particle to the nano-level increases the surface area and improves solubility and dissolution of drug and proportionate increase in the bioavailability of poorly water-soluble drugs. Nicardipine is an antihypertensive drug used as model drug to improve its aqueous solubility, dissolution rate and ultimately bioavailability by preparing solid lipid nanoparticles using solvent hot homogenization method. This review aims to provide readers an overview regarding the feasibility and recent applications of SLNs as an increasing solubility of poorly water-soluble antihypertensive drugs.

Keywords: BCS Class II drug, nanoparticles, Nicardipine, coemulsifier, sacroplasmic reticulum

Cite this Article

Chitra S. Paytode, Vinod M. Thakare. Formulation and Evaluation of Solid Lipid Nanoparticles of BCS Class II Drug. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2019; 6(2): 32–54p.