Design and Evaluation Cefaclor Microspheres for Bioavailability Enhancement

Abstract

This study attempted to formulate microspheres for oral administration of Cefaclor by using different polymers like Hydroxypropyl methylcellulose (HPMC) K4M, (HPMC) K15M and Ethylcellulose (EC) which increases the gastric residence time and thereby the bioavailability. Solvent evaporation method was found to be the best due to its ease of fabrication without compromising the activity of the drug. Cefaclor is a second-generation cephalosporin antibiotic used to treat certain ear, lung, skin, throat and urinary tract infections and also infections caused by bacteria such as pneumonia, septicaemia, meningitis and peritonitis. Fourier Transform Infrared spectroscopy, Differential Scanning Colorimetry and X-ray diffraction study showed that and EC, HPMC K4 and HPMC K15 are compatible. Prepared Cefaclor microspheres by solvent evaporation technique were spherical in shape and size in 116‑130 um. The preparation F1 (72.6%) showed highest entrapment efficiency. The formulations F1 and F4 showed the highest dissolution rate of 76% and the lowest dissolution rate was for F2 with 67.4% at the end of 24 h. In vitro drug release kinetics for preparations, F1-F6 followed zero-order kinetics and the mechanism of drug release was diffusion-controlled. Cefaclor microspheres can be used in sustaining the action of Cefaclor and thereby enhancing its bioavailability.

Keywords: Calibration curve, Cefaclor, drug, electron microscopy, FTIR, HPMC (Hydroxypropyl methylcellulose), microspheres

Cite this Article

Amutha Gnana Arasi M.A., Vikram Pemula, Gopal Rao M. Design and Evaluation Cefaclor Microspheres for Bioavailability Enhancement. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2019; 6(3): 39–48p.