Phytochemical and Neuroprotective Activity of Annona reticulata Leaf Extract in Gentamicin-Induced Nephrotoxicity in Wistar Rats

Abstract

Natural products are an important source of bioactive compounds and have potential for the development of novel therapeutics. Natural products and their derivatives represent more than 50% of all drugs in clinical use in the world. Herbal plants contain and produce a variety of chemical substances that are used as a remedy for treating diseases. Annona reticulata contain different chemical constituents but does not contain glycosides, alkaloids and phytosterols. Various drugs are available in the market for nephroprotective activity but none of the drug is up to the mark for showing its efficacy. In the present examination, treatment of rodents with ethanolic concentrate of underlying foundations of A. reticulata significantly (p<0.05 in 200 mg/kg b.w. what's more, p<0.01 in 400 mg/kg b.w.) diminished the degrees of serum glutamic pyruvic transaminase (SGPT) in the serum which means nephroprotective movement. Serum glutamic oxaloacetic transaminase (SGOT) is a mitochondrial catalyst discharged from the heart, liver, skeletal muscle and kidney. Nephropoisonous quality raised the SGOT levels in the serum because of the harm to the tissues delivering intense corruption; for example, extreme viral hepatitis and intense cholestasis. Alcoholic liver harm and cirrhosis can likewise connect with gentle to direct height of transaminase.

Keywords: Annona reticulata, gentamicin, natural products, nephroprotective activity, phytochemical screening

Cite this Article

Keerthi Laxmi, P. Polereddy, Vivek V. Byahatti. Phytochemical and Neuroprotective Activity of Annona reticulata Leaf Extracts in Gentamicin-Induced Nephrotoxicity in Wistar Rats. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2019; 6(3): 30–38p.