A Review on the Clinical and Pathological Significance of Prorenin Receptor [(P)RR]

Abstract

The (pro)renin receptor (P)RR discovery, which is a novel constituent of Renin Angiotensin-Aldosteron System (RAS) has brought renin and (pro)renin back into spotlight. The (P)RR binds both renin and its inactive precursor (pro)renin, this binding triggers a cascade of intracellular signalling that eventually leads to upregulation of the expression of profibrotic genes, potentially leading to pathogenesis of cardiac and renal fibrosis, growth and remodelling. Clinically, it is also seen that prorenin secreted from the extrarenal tissues like adrenal, ovary, placenta testis, and retina increases 100 folds during diabetes. It has been proved in transgenic animals that the over expression of (P)RR in smooth muscle cells develops hypertension, glomerulosclerosis and kidney damage. Furthermore, the early embryonic lethality seen in (P)RR null mice suggests that (P)RR has additional essential cellular functions. Although, identification of (P)RR has improved our understanding of the physiology of the tissue RAS, its role in pathology is far from clear. Hence (P)RR is a major spotlight in the area of clinical and pathological science, and it can be used for the target oriented drug discovery too.

Keywords: Prorenin receptor, prorenin, renin, handle region peptide

Cite this Article

Iswar Hazarika, Anju Das. A Review on the Clinical and Pathological Significance of Prorenin Receptor [(P)RR]. Research & Reviews: Journal of Pharmacology. 2015; 5(2): 11–17p.