Anti-Ulcer Activity of Ethanolic Extract of Sesamum indicum Seed on Indomethacin-Induced Ulcer Model and Its Antioxidant Property in Gastro-Protection

Abstract

The present study was intended to investigate and evaluate the antiulcer activity of the ethanol seed extract of Sesamum indicum Linn. using Indomethacin Induced Ulcer in Albino rats and to determine its link between oxidant or antioxidant parameter. The extract of Seamum indicum Linn. was tested on indomethacin induced gastric ulcer in Albino rats. The antiulcer activity of high dose (400 mg/kg) and low dose (200 mg/kg) of ethanolic extract of Seamum indicum Linn. was assessed by measuring the ulcerative area and percentage reduction of ulcerative area, which was compared with a standard drug misoprostol. To determine the underlying mechanism for its antiulcer activity, the oxidant/antioxidant parameters like glutathione peroxidase (GPO), superoxide dismutase (SOD), catalase (CAT), myeloperoxidase (MPO), malondialdehyde (MDA) and glutathione (GSH) enzyme were measured in the gastric tissues. Pretreatment of ethanolic extract both high dose and low dose showed significant (p<0.001) decrease in the ulcerative area as compared to the control and was almost as effective as the standard Misoprostol. In rats given ethanolic extract, all of the investigated antioxidant parameters increased, except for catalase (CAT). Conversely, aside from myeloperoxidase (MPO), all oxidant parameters decreased. In conclusion, the antiulcer activity of Sesamum indicum Linn. may be due to its antioxidant property.

Keywords: Sesamum indicum Linn. Indomethacin induced ulcer, Ulcer area, Superoxide dismutase, Catalase, Glutathion

Cite this Article

Iswar Hazarika, Monowar Hussain,Anju Das. Anti-Ulcer Activity of Ethanolic Extract of Sesamum Indicum Seed on Indomethacin-Induced Ulcer Model and its Antioxidant Property in Gastro-Protection. Research & Reviews: Journal of Pharmacology. 2015; 5(2): 18–25p.