Phytochemical Screening and Anticonvulsant Activity of Sebastiania chamaelae

Abstract

Epilepsy is one of the most common serious neurological conditions. Here, phytochemical screening and anticonvulsant activity of Sebastiania chamaelea evaluated. The present study was undertaken to screen anticonvulsant activity of Sebestiana chamelea. The drug was administered in the form of hydro-alcoholic extract orally and the effect was noted at two doses. The drug was found quite safe by the oral route as animals tolerated drug up to the dose of 2.00 gm. Following interpretations are worth of note in the present study: The drug is quite safe by the oral route as animals tolerated drug up to the dose of 2.00 gm/kg body weight in rats. The drug showed significant antiepileptic activity in both strychnine induced seizures. The antiepileptic effect was more pronounced at a higher dose of the test drug than the lower dose. The drug at a higher dose protected the entire animal from death and percent protection from death in the lower dose was 33%. The present study indicated that Sebestiana chamelea has a potential for developing it as an antiepileptic drug, however more refined studies are needed to evaluate it for exact mechanism of action and chemical constituent of Sebestiana chamalea responsible for the antiepileptic action.

Keywords: anticonvulsant activity, antiepileptic activity, phytochemical screening, Sebastiania chamaelae, Wistar Albino rat’s strychnine

Cite this Article

K. Sai Sankeerthana, P. Polereddy, Vivek V. Byahatti. Phytochemical Screening and Anticonvulsant Activity of Sebastiania chamaelae. Research & Reviews: A Journal of Pharmacognosy. 2019; 6(3): 23–28p.