Open Access
Subscription or Fee Access
Long Acting Depot Formulation: History, Mechanism, its Manufacturing and Market Review
Abstract
Patient compliance is a very important factor in the treatment of any disease. Specially in
treatment of chronic diseases such as cancer, arthritis, psychosis patient need to take medicine
for longer time. In such cases long-acting depot injection became excellent option for treatment.
This drug delivery involves drug release over a period of several weeks and months. These depot
formulations can be prepared by using biodegradable polymer Poly (lactide-co-glycolide)
PLGA. Various methods are widely used for preparation of drug containing PLGA
microspheres such as solvent evaporation and solvent extraction method, spray drying method,
double emulsion method, phase separation coacervation technique. Depot injections can be
given through intramuscular and subcutaneous route which further releases drug over a period
of time.
Keywords: biodegradable polymers, depot injections, chronic diseases, long acting drug
delivery
Cite this Article
Ugale JB, Kshirsagar SJ. Long Acting
Depot Formulation: History, Mechanism,
its Manufacturing and Market Review.
Research & Reviews: A Journal of
Pharmaceutical Science. 2019; 10(1): 36–
46p.
References
Amaresh, P., Gupta, B.K., The Plackett-Burman model-An Improved Alternative to Identify the Significant Factors Implied in the Preparation of Tramadol Hydrochloride Microsphere. Indian Journal of Pharmaceutical Education and Research. 2016; 50, 295-300p.
Gupta. P.K., Hung. C.T., Albumin microspheres I: Physicochemical characteristics. Journal of Microencapsulation. 1989; 6, 427-462p.
Thakur. V., Sharma. S., Dextran Microspheres as a Potential Carrier for Vincristine Sulphate Incorporated with Thermosensitive Gel offered Prolonged Release. Research & Reviews: Journal of Pharmacology and Toxicological Studies. 2016; 4, 18-21p.
Skiba. M., Bounoure F., Development of cyclodextrin microspheres for pulmonary drug delivery. J Pharm Pharmaceut Sci. 2005; 8 (3), 409-418p.
Yun. Y., Goetz. D., Hyaluronan microspheres for sustained gene delivery and site-specific targeting. Biomaterials 2003; 25, 147–157p.
Illum. L., Davis., S., Cellulose microspheres as a sustained release system for parenteral administration . Internuti~ai Journal uf Piiarmaceutics, 1982; 11, 323-327p.
Dash. S., Khan. A., Formulation And In-Vitro Evaluation Of Sustained Released Glibenclamide Microspheres. International Journal of Pharmaceutical Sciences and Research. 2012; 3(5) 1433-1443p.
Lemoine. D., Wauters. F., Preparation and characterization of alginate microspheres containing a model antigen. International Journal of Pharmaceutics 1998; 176, 9–19.
Wang. F., He. S., Retinoic acid-loaded alginate microspheres as a slow release drug delivery carrier for intravitreal treatment. Biomedicine & Pharmacotherapy 2018; 97, 722–728p.
Nagai. N., Kumasaka. N., Preparation and characterization of collagen microspheres for sustained release of VEGF. J Mater Sci: Mater Med 2010; 21, 1891–1898p.
Li. L., Jiang. G., Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin. Materials Science and Engineering C 2017; 70, 278–286p.
Fei. W., Pai. L., Preparation, Characterization, and in vitro Release of Biodegradable Erythromycin-gelatin Microspheres. Chem. Res. Chinese universities 2008; 24 (2), 196-199p.
Thombre. N., Chaudhari. M., Preparation and Characterization of Rofecoxib microspheres using cross-linked starch as novel drug delivery system. International Journal of PharmTech Research. 2009; 1 (4), 1394-1402p.
Park. S., Kim. S., Preparation and characterization of biodegradable poly(l-lactide)/poly(ethylene glycol) microcapsules containing erythromycin by emulsion solvent evaporation technique. Journal of Colloid and Interface Science 2004; 271, 336–341p.
Blumenthal. P., Manickam. S., Development and characterization of levonorgestrel encapsulated injectable poly glycolic acid microspheres engineered to specific sizes for controlled longer term contraception. American Society for Reproductive Medicine. 2013; 100 (3), 581p.
Jiang. Y., Wang. F., Development of andrographolide loaded PLGA microspheres: Optimization, characterization and in vitro–in vivo correlation. International Journal of Pharmaceutics. 2014; 475, 475–484p.
Wagennar. B., Muller. B., Piroxicam release fkom spray-dried biodegradable microspheres. Biomaterials, 1994; 15 (1), 49-54p.
Sunitha. S., Amareshwar. P., Preparation and evaluation of tramadol hydrochloride microspheres by coacervation phase separation technique using various solvents and nonsolvents. Journal of Global Pharma Technology. 2011; 3 (4), 33‐41p.
Lim. S., Martin. G., Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. Journal of Controlled Release 2000; 66, 281–292p.
Rojnik. T., Frlan. R., Effect of Preparation Temperature in Solvent Evaporation Process on Eudragit RS Microsphere Properties. Chemical & pharmaceutical bulletin. 2005; 53(1), 143—146p.
Tewes. F., Munnier. E., Comparative study of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles prepared by single and double emulsion methods. European Journal of Pharmaceutics and Biopharmaceutics 66, 488–492p.
Erdmann. L., Uhrich. K., Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters). Biomaterials 2000; 21, 1941-1946p.
Andhariya. J., Burgess. D., Recent advances in testing of microsphere drug delivery systems. Expert Opinion on Drug Delivery. 2016; 1744-7593p.
Schwendeman. S., Shah. R., Injectable controlled release depots for large molecules. J Control Release. 2014; 190, 240–253p.
Mao. S., Guo. C., Recent advances in polymeric microspheres for parenteral drug delivery - part 1. Expert Opin. Drug Deliv. 2012; 9 (9), 1161-1176p.
DOI: https://doi.org/10.37591/(rrjops).v10i1.231
Refbacks
- There are currently no refbacks.
Copyright (c) 2019 Research and Reviews: A Journal of Pharmaceutical Science