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Development and Characterization of Bifonazole Nitrate Nanosuspension Loaded Topical Gel
Abstract
Objective: The goal of the present study was to formulate and evaluate nanosuspension-based topical delivery system of bifonazole nitrate (BN) or increased saturation solubility and controlled drug release. Methods: BN nanosuspension was prepared by pearl milling technique using zirconium oxide beads as a milling media, poloxamer 407 as a stabilizer and glycerol as wetting agent. Effect of various process parameters such as, stirring time and poloxamer concentration were optimized. The optimized nanosuspension was lyophilized using mannitol as a cryoprotectant and incorporated into a topical gel using Carbopol 934P as a gelling agent for controlling the drug release. Results: The percentage drug entrapment results showed that entrapment efficiency increases with increase in the surfactant concentration and drug loading decreases with increase in stirring speed. The drug release increased with increase in the surfactant concentration with high rotation speed. Percentage entrapment efficiency and in vitro drug release of optimized formulation was found to be 93.48% and 79.93%, respectively. Prepared gel was clear and showed good homogeneity and pH was found in normal range. The drug release from Bifonazole nanosuspension loaded gel was significantly prolonged by using the gelling system due to the addition of the polymer carbopol 934P and the mechanism of drug release was non-Fickian and it follows Higuchi matrix. Conclusion: BN nanosuspension loaded topical gel showed increased saturation solubility and controlled drug release and consequently avoids its side effects such as burning and itching.
Keywords: Bifonazole nitrate (BN), nanosuspension, topical gel, factorial design, design expert software
Cite this Article
Arun RR, Anjitha PK. Development and Characterization of Bifonazole Nitrate Nanosuspension Loaded Topical Gel. Research and Reviews: A Journal of Pharmaceutical Science. 2018; 9(2):
36–48p.
References
Nagare SK, A review on Nanosuspension: An innovative acceptable approach in novel delivery system, Universal Journal of Pharmacy, 2012; 1(1): 19-31.
Debjit B, Nanosuspension -A Novel Approaches in Drug Delivery System; The Pharma Innovation – Journal, 2012; 1(12): 50-63.
Kamble VA, Nanosuspension A Novel Drug Delivery System; International Journal of Pharma and Bio Sciences, 2010; 1: 352-360.
Soni S, Nanosuspension: An Approach to Enhance Solubility of Drugs, IJPI’s Journal of Pharmaceutics and Cosmetology, 2012; 2(9): 50-63.
Wagh KS, Patil SK, Akarte AK, Baviskar DT, Nanosuspension - A New Approach of Bioavailability Enhancement; International Journal of Pharmaceutical Sciences Review and Research, 2011; 8: 61-65.
Niyaz Basha B, Kalyani Prakasam, Divakar Goli. Formulation and evaluation of Gel containing Fluconazole-Antifungal Agent; International Journal of Drug Development & Research, 2011; 3(4):109-128.
Bhasha SA, Khalid SA, Duraivel S, Bhowmik D, Kumar KS, Recent trends in usage of polymers in the formulation of dermatological gels; Indian Journal of Research in Pharmacy and Biotechnology, 2013, 1(2), 161-168.
Panigrahi L, Ghosal SK, Pattnaik S, Maharana L, Barik BB, Effect of permeation enhancers on the release and permeation kinetics of lincomycin hydrochloride gel formulations through mouse skin; Indian journal of pharmaceutical sciences, 2006, 68(2), 205-211.
Thakur V, Prashar B, Arora S, Formulation and in vitro Evaluation of Gel for Topical Delivery of Antifungal Agent Fluconazole Using Different Penetration Enhancers; Drug Invention Today, 2012, 4(8), 414-419.
Arun Raj.R, Sruthy S Nair JH. Formulation and evaluation of cyclodextrin inclusion complex tablets of carvedilol. Asian J Pharm. 2016;10(2):84–9.
Nakarani M.Misra A.K, Patel J.K, Vaghani S.S. Formulation of Itraconazole nanosuspension and its characterization; DARU vol.18, No.2, 2010.
Hetal Paresh Thakkar, Bindesh Vishnubhai Patel, and Piyush Thakkar, Development and characterization of nanosuspensions of Olmesartan medoxomil for bioavailability enhancement; Journals of Pharmacy and Bioallied Sciences 2011 ; 3(3): 426-434.
Divya Bhanu Parchuri, G.S Shantha Kumar, Divakar Goli, Roopa Karki. Formulation and evaluation of nanoparticulate drug delivery system of Acyclovir for topical drug delivery; World journal of pharmacy and pharmaceutical sciences, 2013, 2 (6), 5602-5617.
Shapali A. Bagde, Namrata C. Jadhav, Manisha S. Karpe, Vilasrao J. Kadam. Formulation and evaluation of topical microsponge based gel of Bifonazole; Indo American Journal of Pharmaceutical Research. 2016.6(04). 5307-5318.
Ammar H O, Ghorab M, El-Nahhas S A and Higazy I M.Pharmaceutical nanotechnology-Proniosomes as carrier system for transdermal delivery of tenoxicum; Internationan Journal of Pharmaceutics, 2011; 405:142-152.
Arun Raj R. and Dr. Jyoti Harindran. Formulation and Evaluation of Carvedilol Solid dispersion Tablets for Solubility Enhancement. Eur J Biomed Pharm Sci. 2017;4(2):337–48.
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DOI: https://doi.org/10.37591/(rrjops).v9i2.76
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