Research and Reviews: A Journal of Pharmaceutical Science
https://pharmajournals.stmjournals.in/index.php/RRJoPS
<p align="center"><a title="RRJoPS" href="http://stmjournals.com/Journal-of-Pharmaceutical-Science.html" target="_blank"><strong>Research and Reviews: A Journal of Pharmaceutical Science (RRJoPS)</strong> </a>is a print and e-journal focused towards the rapid publication of fundamental research papers in all areas of Pharmaceutical Sciences. The Journal intends to publish all recent advancements in the field of Pharmaceutics. It's a triannual journal, started in 2010.</p><p align="center"><strong>eISSN: 2229-7006</strong></p><p align="center"><strong>Journal DOI no.: 10.37591/RRJoPS</strong></p><p align="center"><strong>Indexed in: </strong>DRJI, Citefactor, Journal TOC, Google Scholar</p><p align="center"><strong>Editor-In-Chief</strong></p><p align="center">Dr.Sanjeev V. Deshpande</p><p align="center">Dr D Y Patil Institute of Pharmacy Akurdi Pune, Maharashtra, India 411044</p><p align="center">Email ;principal[at]dypdpharmaakurdi.ac.in</p><p align="center"><a title="Editorial Board" href="/index.php/RRJoPS/about/editorialTeam" target="_blank">COMPLETE EDITORIAL BOARD</a></p><p><strong>Focus and Scope Covers</strong></p><ul><li>Basic pharmaceutical sciences</li><li>Pharmaceutics</li><li>Pharmacokinetics</li><li>Pharmaceutical Engineering</li><li>Pharmaceutical Nanotechnology</li><li>Pharmaceutical Analysis</li><li>Biopharmaceutics</li><li>Pharmacodynamics</li><li>Protein-Peptide chemistry</li><li>Pharmaceutical technology</li><li>Pharmaceutical Toxicology</li><li>Pharmaceutical validation techniques</li><li>Pharmacotherapy</li><li>Pharmacogenomics</li><li>Quality Control</li><li>Drug and Pro-drug design</li></ul><p align="center">All contributions to the journal are rigorously refereed and are selected on the basis of quality and originality of the work. The journal publishes the most significant new research papers or any other original contribution in the form of reviews and reports on new concepts in all areas pertaining to its scope and research being done in the world, thus ensuring its scientific priority and significance.</p><div id="journalDescription"><p align="center"><a title="Peer Review Process" href="/index.php/RRJoPS/about/editorialPolicies#peerReviewProcess" target="_blank">Peer Review Process</a></p><p align="center"><a title="Peer Review Process" href="/index.php/RRJoPS/about/editorialPolicies#peerReviewProcess" target="_blank">Author Guidelines</a></p></div>en-USResearch and Reviews: A Journal of Pharmaceutical Science2229-7006<p align="center"><strong>Declaration and Copyright Transfer Form</strong></p><p align="center">(to be completed by authors)</p><p>I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is <strong>not</strong> under consideration of publication elsewhere.</p><ul><li>I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.</li><li>I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).</li><li>I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.</li><li> I/We also agree to the authorship of the article in the following order:</li></ul><p>Author’s name </p><p> </p><p>1. ________________</p><p>2. ________________</p><p>3. ________________</p><p>4. ________________</p><table width="100%" border="0" cellpadding="0"><tbody><tr><td valign="top" width="5%"><p align="center"> </p></td><td valign="top" width="95%"><p>We Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.</p></td></tr></tbody></table>Analytical Techniques Used In Metabolomic Analysis
https://pharmajournals.stmjournals.in/index.php/RRJoPS/article/view/1367
Comprehensive studies regarding metabolomics provides us ample of information about the structural properties and various other parameters pertaining to the molecule under study. Metabolomics is employed for managing long-term illness such as cancer, diabetes. It’s applications also stretch to treating diseases such as tachycardia along with various cardiovascular diseases. It is used to treat inborn errors of metabolism which are found out in infants. These molecules along with processes of metabolism may be separated from one another, detected, characterized, and quantified with respect to current and swift growth of a variety of testing systems including gas chromatography, High-performance liquid chromatography connected to Mass spectrometry and Nuclear Magnetic Resonance spectroscopy. The optimal results in metabolomics have been shown by using a combination of contemporary instrumental analytical approaches, and it is advantageous for increasing the limitations with regards to observed substances that are not able to accomplished through solitary-analysis procedures. A biofluid specimen can contain several thousand substances and these substances have frequently been detected sensitively and accurately using combined technologies. The broad acceptance and incorporation of metabolomics into biological systems will be accelerated by the continued growth of these analytical techniques. Here, the use of each punctuated methodology is explained, along with its benefits and drawbacks, using particular illustrations. Additionally, the article thoroughly emphasizes the use of comprehensive instruments in metabolomic analysis. The independent and untargeted examination of cell metabolites in specimen samples is known as metabolomics, and it can be seen as an evolutionary change in the field of analytical biochemistry which took place in the post-genomic period. For many years, the study of metabolites has been a crucial component of life science, helping to create techniques for disease diagnosis, phenotypic assessment of varieties and breeds, assurance of the quality for agricultural items, and investigation of the bodily functions of multiple microorganisms. The genomic revolution, which made the genome sequences of entire biological systems available, along with technological advancements in analytical chemistry, however, compelled us to revisit the methods used to analyse metabolites in samples of various life forms. The study of natural metabolites in its whole, or metabolomics, aims to thoroughly recognize and calculate metabolites in a specimen substance. Miniscule-molecule metabolites are intriguing options for understanding the characteristics of diseases because of their significant roles in biological mechanisms.Saurabh S. AvhadYogeshwari AmbekrHemant ChikhaleLaxmikant BorseSreya Kosanam
Copyright (c) 2023 Research and Reviews: A Journal of Pharmaceutical Science
2024-01-102024-01-10143526810.37591/(rrjops).v14i3.1367Paraquat Poisoning: - A Harmful Pesticide Dangerous to Human Being’s For Oral Ingestion
https://pharmajournals.stmjournals.in/index.php/RRJoPS/article/view/1366
<p>Paraquat is a toxic chemical that is widely used as herbicide chemical product which related for agriculture purpose but some people intake oral paraquat poison with might be both accidental or intentional ingestion which leads to severe and often toxicity. It is an herbicide commonly used in India that has lethal consequences even on minimal consumption. The person who consumed paraquat has rate of mortality is high and there is death which frequently seen, This case report and review article which we have worked on it explores the survival chance of person consumption is low even Though immune-suppressants and antioxidants are conventionally used, but there is a no proper evidence to prove survival benefit of these treatment regimens. There is no rational effective antidote for paraquat poison. In sporadic case reports, clinicians have used various treatments, such as antioxidants (high-dose vitamin C or E), N-acetylcysteine, nitric oxide supplement, corticosteroids, cytotoxic agents, or paraquat antibodies in treating paraquat poisoning, with various outcomes.<strong></strong></p>Mohammad Altaf ShareefQadrie ZLG VenkateshwarluG VenkateshK. Satish
Copyright (c) 2023 Research and Reviews: A Journal of Pharmaceutical Science
2024-01-082024-01-08143212510.37591/(rrjops).v14i3.1366Green Therapy: Therapeutic Plants for Treatment of hair loss
https://pharmajournals.stmjournals.in/index.php/RRJoPS/article/view/1365
Concern over hair loss is frequent among individuals of different ages and genders. While various treatments are available for hair loss, therapeutic plants have gained attention in recent years. Green therapy, is successful in boosting hair development and reducing hair loss, as is the usage of therapeutic plants for hair loss treatment. This review explores the causes of hair loss and the different therapeutic plants that are beneficial for hair loss treatment, such as Aloe vera, rosemary, ginseng and saw palmetto, among others. These plants contain natural compounds that can stimulate hair growth, improve scalp health, and reduce inflammation. The use of green therapy for hair loss treatment offers a natural and safe alternative to conventional treatments, and it is becoming increasingly popular among individuals who seek to improve their hair health without harsh chemicals. Furthermore, this review highlights the importance of further research on therapeutic plants for hair loss treatment and encourages the use of natural remedies for hair health.Asghar AliSarita .Shradha VashistMd Salik Noorani
Copyright (c) 2023 Research and Reviews: A Journal of Pharmaceutical Science
2023-12-222023-12-22143265110.37591/(rrjops).v14i3.1365Advancements in Medicinal Approaches for Vitiligo Management: From Ancient Remedies to Modern Therapies
https://pharmajournals.stmjournals.in/index.php/RRJoPS/article/view/1361
Vitiligo, a skin disorder marked by patchy loss of color, poses substantial challenges to physical and mental well-being. Affecting about 1% of the global population with varying prevalence regionally, this condition demands a nuanced understanding for effective treatment. This article delves into vitiligo’s historical roots, tracing references from ancient medical literature to contemporary medicinal approaches. Exploration begins with the classification, symptoms, and diagnostic methods of vitiligo. Pathogenesis hypotheses, including autoimmune and genetic factors, are examined. The study emphasizes the multifaceted impact on patients, considering both physical and psychological aspects. A comprehensive overview of vitiligo management is presented, covering various treatment modalities. Non-surgical options like topical therapy and phototherapy are discussed in detail, highlighting their efficacy and limitations. Surgical interventions, such as punch grafting and cultured melanocyte grafting, are explored as alternative strategies. Throughout the discussion, the evolution of therapeutic strategies is emphasized. From ancient remedies to contemporary advancements, the article underscores the dynamic nature of vitiligo treatment. Understanding historical contexts and embracing innovative approaches enhance healthcare practitioners & ability to address diverse needs, promoting holistic well- being. In conclusion, vitiligo’s complex nature requires a holistic approach to treatment, acknowledging historical perspectives while integrating modern advancements. This nuanced understanding ensures that healthcare strategies evolve to meet the diverse needs of individuals with vitiligo, ultimately improving their overall quality of life.Sandip Gahininath BadadhePreeti KulkarniGanesh S GangardeTejas S Gangarde
Copyright (c) 2023 Research and Reviews: A Journal of Pharmaceutical Science
2023-12-202023-12-201431910.37591/(rrjops).v14i3.1361A Futuristic concept of understanding Biosimilars in the Pharmaceutical Field
https://pharmajournals.stmjournals.in/index.php/RRJoPS/article/view/1353
Biosimilars, which are highly similar versions of approved biologic drugs, are expected to continue their expansion into new therapeutic areas, offering cost-effective alternatives to a wider range of medical conditions. This evolution includes the development of next-generation biosimilars with improved properties, such as enhanced efficacy, safety, and patient convenience. Innovations in drug delivery methods, reduced immunogenicity, and personalized medicine are anticipated to drive the development of biosimilars tailored to individual patient characteristics. Regulatory agencies are refining the approval pathways for biosimilars, aiming for greater clarity and consistency, while interchangeability designations will enhance their adoption. Educational efforts targeting healthcare professionals, patients, and policymakers will build confidence in biosimilars and promote their wider use. Collaboration between biosimilar manufacturers, biopharmaceutical companies, and academic institutions will drive innovation, leading to improved biosimilar products and manufacturing processes. Additionally, the growing role of emerging markets and global regulatory harmonization will further facilitate access to biosimilars worldwide. The biosimilar field's continual evolution promises to enhance patient access to biologic therapies and improve treatment outcomes while contributing to the sustainability of healthcare systems.Mohammed Shakir GhouseMohd Abdul Mugni Danish
Copyright (c) 2023 Research and Reviews: A Journal of Pharmaceutical Science
2023-11-302023-11-30143102010.37591/(rrjops).v14i3.1353An Overview of Emerging Markets and its Impact on Pharmaceutical Marketing
https://pharmajournals.stmjournals.in/index.php/RRJoPS/article/view/1331
Purpose: The purpose of this study is to examine how expanding markets affect pharmaceutical marketing. Pharmaceutical companies have several potential to build their businesses in emerging economies, which are distinguished by their brisk economic development and rising purchasing power. However, these markets also present unique challenges in terms of regulatory frameworks, cultural differences, and access to healthcare. This paper will explore the strategies employed by pharmaceutical companies to navigate these challenges and capture the potential of emerging markets. Additionally, it will discuss the implications of emerging markets for the global pharmaceutical industry and the future trends in pharmaceutical marketing. Methodology/Approach: The study employs a case study methodology and a qualitative research design. The case study was conducted on a leading pharmaceutical company that has been operating in emerging markets for over 20 years. The data for the case study was collected through interviews with key informants from the company, as well as through secondary data sources. Findings: The study found that pharmaceutical companies are increasingly adopting a multi-pronged approach to marketing in emerging markets. This includes partnering with local distributors and retailers, developing culturally-appropriate marketing campaigns, investing in healthcare education and training, and working with governments to improve access to healthcare.The study also found that emerging markets are presenting both challenges and opportunities for pharmaceutical companies. Practical Implications of Study: The study has a number of practical implications for pharmaceutical companies operating in emerging markets. These include: Partner with local distributors and retailers to reach a wider audience. Develop culturally-appropriate marketing campaigns to build trust with consumers. To increase access to healthcare, spend money on healthcare education and training. Assist governments in enhancing the regulatory landscape. Originality: The study is original in its focus on the impact of emerging markets on pharmaceutical marketing. The report also offers a thorough review of the methods pharmaceutical firms use to deal with the opportunities and difficulties posed by expanding markets.Arpit GuptaDr. MehakMahesh Mishra
Copyright (c) 2023 Research and Reviews: A Journal of Pharmaceutical Science
2023-10-232023-10-23143273410.37591/(rrjops).v14i2.1331