Design Approach based Formulation of Deformable Liposomes and their In vitro Skin Permeation

Abstract

Leukemia is the common cause of disease and its worldwide incidence is increasing. Cytarabine pyrimidine nucleoside analogs most widely used for the treatment of leukemia, but the major obstacles to existing treatments are adverse effect and poor patient’s compliances. To provide sustained drug release with minimum side effects and to develop more patients affable formulation, the authors investigated the transdermal delivery of cytarabine through deformable liposomes. The present work demonstrated the design of nanodeformable liposomes bearing cytarabine by design approach to minimize the experimentation. Three levels and three factors full factorial designs were used to get optimized formulation with minimum particle size and maximum entrapment. Optimized nano lipid based formulations of cytarabine were subjected to particle size, morphology and entrapment efficiency assessment. Invitro skin permeation and cell line inhibitory effect of this novel formulation were also determined. It could be confirmed that the developed transdermal formulation nanodeformable liposomes increase the transdermal flux of cytarabine as compared to drug solution or rigid liposomes and could provide a new alternative therapy for leukemia.

Keywords: Transfersomes, cytarabine, deformable liposomes, leukemia, skin permeation

Cite this Article

Rakesh Raj, Pooja Mongia Raj, Alpana Ram. Design Approach based Formulation of Deformable Liposomes and their In vitro Skin Permeation. Trends in Drug Delivery. 2017; 4(3): 14–25p.