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Distinctive approaches for improving the aqueous solubility of BCS class II drugs

Panner Selvam R, Ganesh NS, Prince Shukla, Vineeth Chandy


The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. The greatest dose strength of an immediate release medication is used to determine solubility. Physical and chemical alteration of the medication, as well as other strategies, has all been used to boost the solubility of poorly soluble drugs. The pharmacological qualities, absorption site, and desired dosage form characteristics all influence which solubility augmentation strategy is used. This review article examines various novel ways to improving the solubility of weakly water-soluble compounds.


Solubility, poorly soluble, strategies, absorption

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Surawase RK, Baheti1 BG, Maru AD. Solubility enhancement techniques for poorly water-soluble drugs: a review. Eur J Bio Pharma Sci. 2020; 7(9): 124-36p.

Patel V, Patel R, Shah H, Purohit S, Pawar M, Pathan A. Solubility enhancement of azithromycin by solid dispersion technique using Mannitol and ╬▓-Cyclodextrin. Acta Sci PharmaSci. 2021; 5(4): 48-54p.

Jagtap S, Magdum C, Jadge D, Jagtap R. Solubility Enhancement Technique: A Review. J Pharm Sci & Res. 2018; 10(9): 2205-11p.

R Lobenberg, GL Amidon. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur J Pharma Biopharma. 2000; 50(1): 3-12p.

Fouad SA, Malaak FA, El-Nabarawi MA, Zeid KA, Ghoneim AM. Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically based pharmacokinetic modeling. 2021; 16(1): 1-14p.

Sanjaymitra PVSS, Ganesh GNK. Dissolution and solubility enhancement strategies: current and novel prospective. J Crit Rev. 2018; 5(3): 1-10p.

Gupta R, Jain V, Nagar JC, Ansari A, Sharma K, Sarkar A, Khan MS. Bioavailability enhancement techniques for poorly soluble drugs: a review. Asian J Pharma Res Dev. 2020; 8(2): 75-78p

Alshehria S, Imama SS, Hussaina A. Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents. Drug delivery. 2020; 27(1): 1625-43p

Huang S, Williams RO. Effects of process on the properties of amorphous solid dispersions. AAPS PharmSciTech. 2018; 19(5): 1971-84p.

Tan K, DavisJr DA, Miller DA, Williams III RO, Nokhodchi A. Innovations in thermal processing: hot-melt extrusion and kinetisol® dispersing deck. AAPS PharmSciTech. 2020; 21(312): 1-20p

Crowley MM, Zhang F, Repka MA, Thumma S, Upadhye SB, Kumar Battu S. Pharmaceutical applications of hot-melt extrusion: part I. Drug Dev Ind Pharm. 2007; 33(9): 909-26p.

Li X, Anton N, Arpagaus C, Belleteix F, Vandamme TF. Nanoparticles by spray drying using new innovative technology: The Buchi nano spray dryer B 90. J Control Release. 2010; 147(2): 304-10p.

Tripathi R, Biradar SV, Mishra B, Paradkar AR. Study of polymorphs of progesterone by novel melt sonocrystallization technique: A technical note. AAPS Pharm Sci Tech. 2010; 11(3): 1493-98p.

Bala R, Madaan R, Arora S. Advanced solubility enhancement techniques for poorly soluble drugs. J Pharma Sci Tech. 2017; 7(1): 6-11p.

Adali MB, Barresi AA, Boccardo G, Pisano R. Spray freeze-drying as a solution to continuous manufacturing of pharmaceutical products in bulk. Processes. 2020; 8(709): 1-27p.

Radke R, Jain NK. Melt sonocrystallization a novel technique of solubility enhancement: a review. Int J Pharm Sci Rev Res. 2020; 64(2): 70-75p.

Sopan P, Nilesh M, Purushottam G, Amol W. Enhancement of solubility of diclofenac sodium by pastillation method. J Drug Deli & Therap. 2021; 11(2): 6-10p.

Pandit. PA, Chavan TT, Khandelwal RK. Oral lipid based multipurticulate pastilles: Design and effect of pore former. J Pharma Invest. 2015; 45: 1-9p.

Thakur V, Dogra1 S, Verma S, Vashist HR. Solubility enhancement techniques. World J Pharma Res. 2020; 9(13): 265-82p.

Gaddam M, Ravouru N. A Crystal engineering design to enhance the solubility, dissolution, stability and micromeritic properties of omeprazole via co-crystallization techniques. Research J. Pharm. and Tech. 2021; 14(1): 356-62p.

Patel JN, Rathod DM, Patel NA, Modasiya MK. Techniques to improve the solubility of poorly soluble drugs. Int J Pharm & Life Sci. 2012; 3(2): 1459-69p.

Kumar RS, Sai JD. Liquisolid Compacts: A Review. J Drug Delivery & Thera. 2019; 9(4): 880-83p.

Xing H, Jiang J, Chen X, Yang T, Wang D, Ding P. Liquisolid technique and its applications in pharmaceutics. Asian J Pharma Sci 2017; 12(2): 115-23p

Savkare AD, Bhavsar MR, Gholap VD, Kukkar PM. Liquisolid technique: a review. Int J Pharma Sci Res 2017; 8(7): 2768-75p.


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