Open Access
Subscription or Fee Access
A Review on Biotechnological Aspects of Conservation and Enhancements of Indian Snakeroot (Rauwolfia serpentina)
Abstract
Indian snakeroot (Rauwolfia serpentina) is one of the most important medicinal plants found in the Indian subcontinent, used in the treatment of various types of diseases. Recently it has been considered as a critically endangered plant by the International Union of the Conservation of Nature and Natural Resources (IUCN) due to its heavy exploitation in the past. The plant has a high demand in the international market due to its medicinal properties and abundance of phytochemicals, which means it is necessary to save it from extinction as well as to improve the quality and quantity of the phytochemicals produced by the plant. Indian snakeroot has an abundance of an indole alkaloid–reserpine which can cure hypertension and other mental disorders, some more phytochemicals can be found in the plant but very low concentration. In-vitro micropropagation methods could be a solution for this problem, it could be effectively used in stabilizing the population of the plant as well as. The review is mainly focused on a study of pharmacological aspects of Indian snakeroot, and the biotechnological methods for conservation and enhancements of some endangered medicinal plants.
Keywords
References
Chauhan S, Kaur A, Vyas M, Khatik GL. Comparison of Anti-Diabetic And Anti-Oxidant Activity Of Wild And Cultivated Variety Of Rauwolfia Serpentina. Asian Journal of Pharmaceutical and Clinical Research. 2017: 10 (12): 404–6.
Sharma S, Thokchom R. A review on endangered medicinal plants of India and their conservation. J. Crop Weed. 2014; 10 (2): 205–18.
Gowthami R, Sharma N, Pandey R, Agrawal A. Status and consolidated list of threatened medicinal plants of India. Genetic Resources and Crop Evolution. 2021; 68 (6): 2235–63.
Paramanick D, Panday R, Shukla SS, et al. Primary pharmacological and other important findings on the medicinal plant “Aconitum heterophyllum”(aruna). Journal of Pharmacopuncture. 2017; 20 (2): 89–92.
D. Laloo, A.N. Sahu, S. Hemalatha, et al., “Pharmacognostical and phytochemical evaluation of Cinnamomum wightii Meissn. flowers,” 2012. 3 (1): 33–39.
Gupta S, Sarma S, Mao AA, Seal T. Antioxidant activity of different parts of Lysimachia laxa and Gymnocladus assamicus, a comparison using three different solvent extraction systems. J Chem Pharm Res. 2013; 5 (4): 33–40.
Pandey MM, Rastogi S, Rawat AK. Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant. Journal of ethnopharmacology. 2007; 110 (3): 379–90.
C. Selles, M.A Dib, et al. “Evaluation of antimicrobial and antioxidant activities of solvent extracts of Anacyclus pyrethrum L Natural products View project Study of interaction between enzyme and substrate by using methods of molecular modeling View project Chaouki Selles,” Alger. Artic. Mediterr. J. Chem. 2012; 2 (2): 408–415.
Narasimhulu G, Aishah A, Reddy KS, Mohammed A. A review of recent research of medicinal properties of Pimpinella tirupatiensis Bal. & Subr. an endemic to Tirumala Hills of Eastern Ghats, India. Journal of Pharmacy Research. 2012; 5 (8): 4233–5.
Vaidya AD, Devasagayam TP. Current status of herbal drugs in India: an overview. Journal of clinical biochemistry and nutrition. 2007; 41 (1): 1–1.
Kadam ST, Pawar AD. Conservation of medicinal plants: A review. Int. Ayurvedic Med. J. 2020; 8: 3890–5.
Sarpgandha Rauvolfia Serpentina Benth. Ex.Kurz Family-Apocynaceae.”
Reddy Jagdish, “Sarpagandha Cultivation-A Beginners Guide | Agri Farming,” agrifarming. 2021. https://www.apnikheti.com/en/pn/agriculture/horticulture/medicinal-plants/sarpagandha
Velu G, Palanichamy V, Rajan AP. Phytochemical and pharmacological importance of plant secondary metabolites in modern medicine. InBioorganic phase in natural food: an overview 2018: (pp. 135–156).
Kumari R, Rathi B, Rani A, et al. phytochemical, pharmacological and therapeutic aspects. Int J Pharm Sci Rev Res. 2013; 23 (2): 348–55.
Pathak J, Ahmed H, Kumari N, et al. Role of calcium and potassium in amelioration of environmental stress in plants. Protective Chemical Agents in the Amelioration of Plant Abiotic Stress: Biochemical and Molecular Perspectives. 2020: 535–62.
Y. Sidhu, “In vitro micropropagation of medicinal plants by tissue culture,” Plymouth Student Sci. 2010; 4 (41): pp. 432–449, 2010.
D.S. Uikey, M.K. Tripathi, G. Tiwari, et al “Embryogenic cell suspension culture induction and plantlet regeneration of Rauvolfia serpentina (L.) Benth.: Influence of different plant growth regulator concentrations and combinations,” Med. Plants.2016; 8 (2): 153–162.
R.N. Bahuguna, R. Joshi, G. Singh, et al “Micropropagation and total alkaloid extraction of Indian snake root (Rauwolfia serpentina),” Indian J. Agric. Sci. 2011; 81 (12): 1124–1129, 2011.
Nielsen E, Temporiti ME, Cella R. Improvement of phytochemical production by plant cells and organ culture and by genetic engineering. Plant cell reports. 2019; 38 (10): 1199–215.
Sourabh P. Ethnomedicinal uses and cultivation of Rauvolfia serpentina Benth.: a minireview. Recent advances in medicinal plants and their cultivation. 2012: 153–9.
Rauwolfia serpentina root: Uses, Interactions, Mechanism of Action | DrugBank Online,” Drugbank online.2015. Available online at: https://go.drugbank.com/drugs/DB09363
Panja S, Chaudhuri I, Khanra K, et al. Biological application of green silver nanoparticle synthesized from leaf extract of Rauvolfia serpentina Benth. Asian Pacific Journal of Tropical Disease. 2016; 6 (7): 549–56.
Thakur N, Jagota K, Shama B, Sareen N. Evaluation of in vitro antifungal potential of Rauvolfia serpentina (L). Benth. ex Kurz. against phytopathogenic fungi. Int J Sci Nat. 2015; 6 (2): 165–8.
Sivaraman T, Sreedevi NS, Meenachisundharam S, et al. Neutralizing potential of Rauvolfia serpentina root extract against Naja naja venom. Brazilian Journal of Pharmaceutical Sciences. 2020: 6; 56.
Ray S, Majumder A, Bandyopadhyay M, Jha S. Genetic transformation of sarpagandha (Rauvolfia serpentina) with Agrobacterium rhizogenes for identification of high alkaloid yielding lines. Acta Physiologiae Plantarum. 2014; 36 (6): 1599–605.
S. Ray, A. Majumder, M. Bandyopadhyay, and S. Jha, “Genetic transformation of sarpagandha ( Rauvolfia serpentina ) with Agrobacterium rhizogenes for identification of high alkaloid yielding lines,” Acta Physiol. Plant. 2014; 36 (6): 1599–1605.
Sevón N, Oksman-Caldentey KM. Agrobacterium rhizogenes-mediated transformation: root cultures as a source of alkaloids. Planta Medica. 2002; 68 (10): 859–68.
Guillon S, Tremouillaux-Guiller J, Pati PK, et al. Harnessing the potential of hairy roots: dawn of a new era. TRENDS in Biotechnology. 2006; 24 (9): 403–9.
nology. 2006 ;24(9):403-9.
Refbacks
- There are currently no refbacks.
Copyright (c) 2022 Research & Reviews: A Journal of Drug Design & Discovery