DESIGN AND EVALUATION OF SANDWICH TABLET FOR SUSTAINED RELEASE DRUG DELIVERY OF DICLOFENAC SODIUM.

Authors

  • JAIMIN B. PATEL Reseacrh scholar, GUJARAT TECHNOLOGICAL UNIVERSITY
  • MR. BHAVIN BHIMANI
  • DR. HIREN KADIKAR
  • DR. UPENDRA PATEL

Keywords:

Bilayer sandwich tablet, Diclofenac sodium, PH independent Polymer, HPMC K4M

Abstract

The objective of this experiment was to create bilayer sandwich pills using the model medication diclofenac. A lengthy duration of action is provided by the combination of an immediate and sustained release layer, which lengthens the effect in the body. Diclofenac sodium has excellent antipyretic, analgesic and anti-inflammatory effects. A super disintegrating carboxyl agent, such as methyl cellulose, is used for the quick release layer of a bilayer sandwich tablet containing diclofenac sodium, and a pH independent polymer, such as HPMC K4M, is used for the maintenance layer. Before and after compression, the tablets were evaluations for a number of factors, including weight fluctuation, thickness, hardness, friability, and in vitro drug release.

References

W. C. Gunsel. Compression-coated and layer tablet. In A.H. Lieberman (ed.), Pharmaceutical dosage forms: tablets, Decker, New York, 1989, pp. 274–284.

Theodore JR, Mansdorf SY. Controlled release drug delivery system. New York: Marcel Dekker; 1983.

Donald LW. Bioploymeric controlled release system. Vol I. USA: CRS press Inc; 1984.

James MA, Sung Wankim. Advances in drug delivery systems. Controlled release series-1. New York: Elsevier; 1980.

Theeuwes FG, Higuchi T. Fabrication of sustained release dosage form. U.S. patent No. 3,845,770.

Robinson JR. Sustained and controlled release drug delivery system, New York: Marcel dekker Inc; 1978.

Chien YW. Rate controlled drug delivery systems. 2nd ed. New York: Marcel Dekker; 2005.

Ballard BE. Prolonged action pharmaceuticals. Pennsylvania: Mack publishing company; 1980.

Lippincott Williams, Wilkins. Remington. The science and Practice of pharmacy. 20th Edition. Vol II; 2000.

Robinson. JR, Lee LH. Controlled drug delivery, fundamentals and applications. Newyork: Marcel dekker Inc; 1987.

Rang HP, Dale MM, Ritter JM, More PK. Pharmacology. 5th ed. United Kingdom: Churchill Livingston; 2003.

Hoffman A. Pharmacodynamic aspects of sustained release preparations. Adv Drug Del Rev 1998;33:185-99.

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Published

2023-09-15

Issue

Vol. 10 No. 2 (2023)

Section

Research Article

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