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Rivaroxaban: A Comprehensive Review of an Anticoagulant Revolution

Dr. Himanshu Solanki, Nimisha Vala, Shruti Adhikari, Neha Patil, Jaydatta Dhakane, Ajinkya Thakare

Abstract


Rivaroxaban, a prominent direct oral anticoagulant (DOAC), has garnered attention for its pivotal role in preventing and treating thromboembolic diseases. Its introduction into clinical practice has marked a significant advancement in anticoagulant therapy. The mechanism of action of rivaroxaban involves selective inhibition of factor Xa, a crucial component in the coagulation cascade. This targeted approach distinguishes it from traditional anticoagulant and contributes to its efficacy. The significance of rivaroxaban lies in its short half-life, consistent bioavailability and rapid absorption, rivaroxaban is especially remarkable since they provide converting dosage on a daily basis. Analysing actual scenarios demonstrates rivaroxaban’s dependability and efficacy in contemporary therapeutic practice. This research explores its pharmacokinetics and pharmacodynamic properties make it even more useful and contribute to a more complex understanding of its role. A thorough examination of its pharmacological profile sheds lights on its reliability and efficacy in a range of medical contexts. Furthermore, an accurate understanding of rivaroxaban’s role in anticoagulant therapy can be acquired by looking through significant papers and patents. An in-depth analysis of rivaroxaban pharmacological profile illuminates its reliability and efficacy across various medical scenarios. The study considers the drugs role in anticoagulant therapy, shedding light in its application and benefits. By reviewing pertinent papers and patents, an accurate understanding of rivaroxaban position in the realm of anticoagulation therapy is attained, further emphasizing its clinical importance. In conclusion, this research provides a comprehensive insight into rivaroxaban pharmacokinetics and pharmacodynamics, establishing its role as a crucial agent in the management of thromboembolic diseases.

Keywords


Rivaroxaban, Anticoagulant, Factor Xa, Atrial fibrillation, Venous thromboembolism.

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References


Hosny N. A review on: analysis of the first oral, direct factor Xa inhibitor; Rivaroxaban. Microchem. J. 2020; 159:1-8p.

Günther A, Ruppert C. Anticoagulants In: Sam Janes, editors. Encyclopedia of Respiratory Medicine: 2nd Edn. Amsterdam, Netherlands: Elsevier Inc; 2006.

Beyer-Westendorf Jan, Förster K, Pannach S. et al. Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry. Blood, The Journal of the American Society of Hematology. 2014;124(6):955-62p.

Fredenburgh J, Weitz J. New anticoagulants: moving beyond the direct oral anticoagulants. JTH. 2021;19(1):20-9p.

Antoniou S. Rivaroxaban for the treatment and prevention of thromboembolic disease. J. Pharm. Pharmacol. 2015;67(8):1119-32p.

Vílchez J, Gallego P, Lip G. Safety of new oral anticoagulant drugs: a perspective. Ther. Adv. Drug Saf. 2014 Feb;5(1):8-20p.

Haas S, Bode C, Norrving B, Turpie A. Practical guidance for using rivaroxaban in patients with atrial fibrillation: balancing benefit and risk. Vasc Health Risk Manag. 2014:101-14p.

Reçber T, Haznedaroğlu İ, Çelebier M. Review on characteristics and analytical methods of rivaroxaban. Critical Reviews in Analytical Chemistry. 2022;52(4):865-77p.

Douxfils J, Mullier F, Loosen C, Chatelain C, Chatelain B, Dogné J. Assessment of the impact of rivaroxaban on coagulation assays: laboratory recommendations for the monitoring of rivaroxaban and review of the literature. Thromb. Res. 2012;130(6):956-66p.

Jaffray J, Young G. Direct oral anticoagulants for use in paediatrics. Lancet Child Adolesc Health. 2022; 1-16p.

Samama M, Contant G, Spiro T. et al. Laboratory assessment of rivaroxaban: a review. Thromb. J. 2013;11(1):1-7p.

Bardy G, Fischer F, Appert A. et al. Is anti-factor Xa chromogenic assay for Rivaroxaban appropriate in clinical practice? Advantages and comparative drawbacks. Thromb. Res. 2015;136(2):396-401p.

Perzborn E, Roehrig S, Straub A, Kubitza D, Mueck W, Laux V. Rivaroxaban: a new oral factor Xa inhibitor. ATVB. 2010;30(3):376-81p.

Kreutz R. Pharmacokinetics and pharmacodynamics of rivaroxaban–an oral, direct factor Xa inhibitor. Curr. Clin. Pharmacol. 2014;9(1):75-83p.

Kreutz R. Pharmacodynamic and pharmacokinetic basics of rivaroxaban. Fundam. Clin. Pharmacol. 2012;26(1):27-32p.

Trujillo T, Dobesh P. Clinical use of rivaroxaban: pharmacokinetic and pharmacodynamic rationale for dosing regimens in different indications. Drugs. 2014; 74: 1587-1603p.

Bratsos S. Pharmacokinetic properties of rivaroxaban in healthy human subjects. Cureus. 2019;11(8):1-6p.

Fahmi A, Elewa H, El Jilany I. Warfarin dosing strategies evolution and its progress in the era of precision medicine, a narrative review. Int. J. Clin. Pharm. 2022;44(3):599-607p.

Coleman C, Turpie A, Bunz T, Eriksson D, Sood N, Baker W. Effectiveness and safety of rivaroxaban vs. warfarin in non-valvular atrial fibrillation patients with a non-sex-related CHA2DS2-VASc score of 1. EHJ-CVP. 2019;5(2):64-9p.

Abraham N, Singh S, Alexander G, Heien H, Haas L, Crown W, Shah N. Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: population-based cohort study. bmj. 2015;1-9p.

Baytas S, Linhardt R. Advances in the preparation and synthesis of heparin and related products. Drug Discov. Today. 2020;25(12):2095-109p.

Qiu M, Huang S, Luo C. et al. Pharmacological and clinical application of heparin progress: An essential drug for modern medicine. Biomed. Pharmacother. 2021;139:1-17p.

Lv S, Liu Y, Wei G, Shi X, Chen S, Zhang X. The anticoagulants rivaroxaban and low molecular weight heparin prevent PICC-related upper extremity venous thrombosis in cancer patients. Medicine. 2019;98(47):1-7p.

Samama M. The mechanism of action of rivaroxaban-an oral, direct Factor Xa inhibitor–compared with other anticoagulants. Thromb. Res. 2011;127(6):497-504p.

Heo Y. Andexanet alfa in the treatment of acute major bleeding related to apixaban and rivaroxaban: a profile of its use in the USA. Drugs Ther. Perspect. 2018; 34: 507-12p.

Bonde A, Martinussen T, Lee C. Rivaroxaban versus apixaban for stroke prevention in atrial fibrillation: an instrumental variable analysis of a nationwide cohort. Circ.: Cardiovasc. Qual. Outcomes. 2020;13(4): 58-67p.

Bai Y, Deng H, Shantsila A, Lip G. Rivaroxaban versus dabigatran or warfarin in real-world studies of stroke prevention in atrial fibrillation: systematic review and meta-analysis. Stroke. 2017;48(4):970-6p.

Zhou Y, Yao Z, Zhu L, Tang Y, Chen J, Wu J. Safety of dabigatran as an anticoagulant: a systematic review and meta-analysis. Frontiers in Pharmacology. 2021;12: 1-10p.

Li B, Reynolds T, inventors; Mylan Inc, assignee. A unique high-shear granulation process for improved bioavailability of rivaroxaban. United States patent application US 16/076,454. 2019 Feb 14; 1-6p.

Keshav S, bhise S, Kamble H, Chaudhari G, Patil D, Bhushan KH, Bhirud SB, Sanikommu SR, inventors; Glenmark Pharmaceuticals Limited, Glenmark Generics Limited, assignee. Process for the preparation of rivaroxaban. 2014 Oct 2; 1-32p.

Ferrari, Massimo, Ghezzi, Emanuele, Maecello inventors; Erregierre S.P.A. via F. baracca. Process for the synthesis of Rivaroxaban and intermediate for the production thereof. 2015 dec 30; 1-10p.

Singh RK, Garg T, Chithambaram M, Kumar A, inventors; Mankind Pharma Ltd, assignee. Pharmaceutical compositions of rivaroxaban. United States patent application US 17/188,401. 2021 Sep 2; 1-8p.

Menichetti M, Rosso S, Menegatti E, Pazzaglia M. Use of rivaroxaban in an elderly patient with intermediate-low early mortality risk due to pulmonary embolism: a case report. J. Med. Case Rep. 2015; 9: 1-5p.

Yamaguchi J, Hara N, Yamaguchi T, Nagata Y, Nozato T, Miyamoto T. Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency. J. Cardiol. Cases. 2017;16(5):144-7p.

Scarano M, Casale M, Mantini C. et al. Rivaroxaban as an effective alternative to warfarin in a patient with atrial fibrillation, thrombophilia, and left atrial appendage thrombus: a case report. J. Med. Case Rep. 2017;11(1):1-4p.


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