Single Nucleotide Polymorphism in CYP17 and CYP19 in Breast Cancer

Authors

  • JENIFER SOLOMON RAJAN Department of Biotechnology, Bon Secours College for Women’s, Thanjavur, TamilNadu, India
  • Laveena D. K. Department of Biotechnology, Bon Secours College for Women’s, Thanjavur, TamilNadu, India
  • Singh S. J. S Bishop Heber College Trichy, Tamilnadu, India

Abstract

A single T > C change at the 5’ promoter region of  the CYP17 and CYP19  genes are reported to be associated with increased risk of breast cancer. This study evaluates the influence of genetic polymorphism of CYP17 and CYP19 on breast cancer susceptibility. Ten patients with histopathologically confirmed breast cancer and 30 age-matched controls were included in study. A polymerase chain reaction – single nucleotide polymorphism (PCR-SSCP) method was used to detect the polymorphism.

 

Keywords: CYP17 and CYP 19 subunits of Cytochrome 450, SSCP single strand conformational polymorphism

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Published

2019-02-28

Issue

Vol. 1 No. 2 (2014)

Section

Research Article

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