Formulation and In vitro Evaluation of Oral Fast Dissolving Tablets of A Novel Antidepressant Drug by Using Camphor As A Subliming Agent

Authors

  • Mudit Dixit Department of Pharmaceutics, NGSM Institute of Pharamceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India
  • CR Narayana Department of Pharmaceutics, NGSM Institute of Pharamceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India
  • Nayak P Department of Pharmaceutics, NGSM Institute of Pharamceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India
  • Dixit M Department of Pharmaceutics, NGSM Institute of Pharamceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, India

Abstract

The purpose of the present investigation is to formulate fast dissolving tablets of Venlafaxine HCl, a novel antidepressant by direct compression method using camphor as subliming agent in the three different concentrations of 2%, 5% and 10%. Croscarmellose, tulsion-414 and sodium starch glycolate were used as superdisintegrants in two different concentrations of 5% and 10%. The drug-excipients compatability was ruled out through FTIR studies. A total of six formulations were prepared with different concentrations of camphor and superdisintegrants. The prepared tablets were evaluated for thickness, hardness, friability, weight variation, drug content and in vitro dispersion time, wetting time and in vitro drug release. All the evaluation parameters were found to be within the limits of IP specifications. The disintegration time was found to be linearly decreases with the increase in the amount of superdisintegrant and camphor whereas the dissolution rate linearly increases. Among all the six formulations the tablets formulated with sodium starch glycolate with camphor were shown highest percentage of drug release within 10 minutes. It was concluded that oral fast dissolving tablets of Venlafaxine HCl can be successfully formulated by direct compression with camphor as subliming agent.

 

Keywords: Venlafaxine HCl, camphor, superdisintegrants, sublimation

Cite this Article

Sandeep SD, Narayana CR, Nayak P et al. Formulation and In vitro evaluation of oral fast dissolving tablets of a novel antidepressant drug by using camphor as a subliming agent. Research & Reviews: A Journal of Drug Design and Discovery. 2015; 2(3): 12–18p.

Downloads

Published

2019-03-02

Issue

Vol. 2 No. 3 (2015)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.