Molecular Docking Study of Curcumin-Sugar Conjugates as Cholesterol Biosynthesis as well as Staphylococcus Aureus Virulence Inhibitor

Authors

  • Ruchika Goyal Drug Discovery and Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
  • Sandeep Jain Department of Pharmaceutical Sciences, Drug Discovery and Research Laboratory, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

Abstract

Methicillin resistant Staphylococcus Aureus infections are the major concern in both, communities as well as in clinics. Presqualene diphosphate is the key molecule obtained from farnesyl diphosphate for the biosynthesis of staphylophyloxanthin which is responsible for the virulence of Staphylococcus Aureus as well as for cholesterol biosynthesis in humans. We designed some natural curcumin-sugar conjugates that binds to the protein associated with the formation of presqualene diphosphate and inhibit it, thus showing dual role by inhibiting staphylococcus aureus virulence and also helps in lowering cholesterol formation in humans.

 

Keywords: Staphylococcus aureus, curcumin, docking, iGEMDOCK, AutoDOCK, AutoDockVina

Cite this Article

Ruchika Goyal, Sandeep Jain. Molecular Docking Study of Curcumin-Sugar Conjugates as Cholesterol Biosynthesis as well as Staphylococcus Aureus Virulence Inhibitor. Research & Reviews: A Journal of Drug Design & Discovery. 2017; 4(1): 15–21p.

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Published

2019-03-04

Issue

Vol. 4 No. 1 (2017)

Section

Research Article

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