An Insight to Animal Models of Drug Induced Schizophrenia

Authors

  • Ashmun Nisha
  • Anuradha Mishra Faculty of Pharmacy, Integral University, Lucknow, 226026
  • Afreen Usmani
  • Salman Khan

Abstract

Schizophrenia is a mental disorder that generally shows in early adulthood or late adolescence characterized by hallucinations, delusions, and other cognitive dysfunctions, schizophrenia can often be a lifelong problem. Schizophrenia affects approx. 1% of all adults, universally. The purpose of this article is to review several drug induced schizophrenia animal models. The scientific study of human disorders has required the development of suitable animal models. The prevailing recent view of neuroscience, for which there is extensive experimental data, is those clinically related psychiatric situations have at their cause a primary dysfunction of neuronal systems. The certain interruption in neuronal activity can affect both animal and human behavior; animal models can be developed for evaluating various prognostic and causative theories that cannot be performed in human studies. The development of predictive and reliable animal models for complex psychiatric disorders, i.e., schizophrenia, is important to enhance our perceptive of the neurobiological basis of the disorder and for the development of novel drugs with enhanced therapeutic efficacy.

 

Keywords: Schizophrenia; hallucinations; cognitive dysfunctions; neurobiological

Cite this Article

Ashmun Nisha, Anuradha Mishra, Afreen Usmani, Salman Khan. An Insight to Animal Models of Drug Induced Schizophrenia. Research & Reviews: A Journal of Drug Design & Discovery. 2019; 6(1): 21–33p.

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Published

2019-05-17

Issue

Vol. 6 No. 1 (2019)

Section

Research Article

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