Synthesis and Antimicrobial Evaluation of Novel Benzimidazolyl Chalcones

Authors

  • Taher Patel Department of Pharmaceutical Chemistry,Gland Institute of Pharmaceutical Sciences,Telangana, India
  • Nagaraju D. Department of Pharmaceutics,Gland Institute of Pharmaceutical Sciences,Telangana, India
  • N Siva Subramanian Department of Pharmaceutical Chemistry,Gland Institute of Pharmaceutical Sciences,Telangana, India
  • Sindhuja Savasani Department of Pharmaceutical Chemistry,Gland Institute of Pharmaceutical Sciences,Telangana, India

Abstract

A new synthesis of benzimidazolyl chalcones derivatives of N1-[4-(1H-benzo[d]imidazol-2-yl) phenyl] derivatives were synthesized. These compounds have been characterized by detailed IR and NMR spectral analysis and have been screened for their antimicrobial activity in-vitro against bacterial Strains of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, and Bacillus subtelis, and fungal strains of Aspergillus niger and Candida albicans were used. Most of the tested compounds exploited potent antimicrobial activity with MIC values in the zone of inhibition in mm, in particular compound 3a, 3d, 3f, 3g and 3h showed remarkable activity toward the bacterial strains and 3b, 3c, and 3d showed remarkable activity towards the used fungi species.Among the tested compound 3g and 3h showing good inhibition.

 

Keywords: 6, 7-dialkoxy-4-anilinoquinazolines, Antibacterial activity, IC50

 

Cite this Article

Taher Patel, Nagaraju D., N Siva Subramanianet al.Synthesis and Antimicrobial Evaluation of Novel Benzimidazolyl Chalcones.Research & Reviews: A Journal of Drug Design & Discovery. 2017; 4(3): 22–29p.

References

Naveenkumar CR, PhD Thesis, “Synthesis of the N1-substituted quinolones, N1-quinolone dimmers and C-6 substituted pyrazolo pyrimidines as antibacterial activity”, Jawaharlal Nehru Technological University, June 2011.

Patrick GM. An Introduction to Medicinal Chemistry; Oxford University Press, New York,2,375-431,2001.

Fanmy H H and Abdelwad S H, Molecules., 2000, 5,1429.

Tebbe M J and Spiyzer W A, J Med Chem., 1997, 40, 3937.

Subudhi B B, Panda P K, Kundu T, Sahoo S and Pradhan D, J Pharm Res., 2007, 6, 114.

Aydin S, Beis K and Can D D, Pharmazie., 2003, 58, 405.

R.S.Varma “ Microwaves in Organic Synthesis ,Chap. 6 , Wiley –VCH , Weinheim , PP-181.(2002).

Bhagyesh B., Sureshbhi P., SS Khadabadi, Designand Synthesis of Some Novel Chalcones as Potent Antimicrobial Agent, Asian J. Research Chem.1(2): Oct.-Dec. 2008.

Reddy, A. C. S.; Rao, P. S.; Venkataratnam, R. V.Microwave-assisted synthesis of benzimidazole, Tetrahedron Lett. 1996, 37, 2845.

Xia Y, Yang Z-Y, Xia P, Bastow KF, Nakanishi Y, Lee K-H: Antitumor Agents. Part 202: Novel 2′-Amino Chalcones: Design, Synthesis and Biological Evaluation. Bioorg. Med. Chem. Lett. 2000, 10:699-701.

Li R, Chen X, Gong B, Dominguez JN, Davidson E, Kurzban G, Miller RE, Nuzum EO, Rosenthal PJ:In Vitro Anti malarial Activity of Chalcones and Their Derivatives. J. Med. Chem. 1995, 38:5031-5037.

Downloads

Published

2018-03-17

Issue

Vol. 4 No. 3 (2017)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.