Review on Zebrafish Model: A Novel Research Tool

Authors

  • K. Purna Nagasree Vignan Institute of Pharmaceutical Technology
  • K. Santhi

Abstract

Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from South Asia. The ease of care, year‐round prolific breeding, and transparent, external development have made these fish a popular model vertebrate for many fields of biology. Over the past 40years, the development methods for genetics, CNS system, CVS system and cancer and other researches have shown rapid development. This review provides an orientation to the zebrafish as a model system, from its ecology and life history to its early use in research and adoption as a key genetic model for vertebrate development. The mice and rats have been common choices for modelling human diseases in the past; the use of zebrafish was rapidly gaining popularity in humans. 70% of human genes’ similarities are found in zebrafish and also this fish has organs similar to human.

 Keywords: Cancer, CNS, CVS, genes, liver, zebrafish

 Cite this Article

K. Purna Nagasree, K. Santhi2. Review on Zebrafish Model: A Novel Research Tool. Research & Reviews: A Journal of Drug Design & Discovery. 2019; 6(3): 18–30p.

Author Biography

  • K. Purna Nagasree, Vignan Institute of Pharmaceutical Technology

    Medicinal Chemistry and drug discovery laboratory

    Associate Professor and HOD

Downloads

Published

2020-01-10

Issue

Vol. 6 No. 3 (2019)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.