Evaluation of Antiulcer Activity of Allamanda cathartica Aqueous Leaf Extract in Experimental Rat Models

Abstract

A peptic ulcer is an open sore that forms on an epithelial surface of the stomach. To decrease the incidence of relapses, side effects, drug interactions of the existing drugs, and to increase the use of available phytochemicals, this present study was aimed to evaluate the antiulcer activity of Allamanda cathartica using pyloric ligation induced gastric ulcer model and Aspirin-induced gastric ulcer model. In pyloric ligation induced gastric ulceration model, Group I receives distilled water. Group II receives ranitidine 50 mg/kg, p.o. Group III and IV receive Allamanda cathartica aqueous leaf extract (ACALE) at 250 mg/kg and 500 mg/kg, p.o, respectively for 7 days. In the Aspirin-induced gastric ulcer model, Group I receive 1% CMC, Group II receive Aspirin (100 mg/Kg, p.o), Group III receive ranitidine (50 mg/kg, p.o), Group IV and Group V receive ACALE at 250 and 500 mg/kg, p.o along with Aspirin. ACALE consists of flavonoids, alkaloids. ACALE 500 mg/kg had shown antiulcer activity on pyloric ligation induced experimental models by decreasing the effect of gastric acid on GIT (Gastro-Intestinal Tract) and by its antisecretory activity. In the Aspirin-induced gastric ulcer model, Group IV and V had shown a decrease in ulcer index, increased ulcer protection, decrease in gastric acidity parameters. The findings of the present study conclude that the phytochemicals, within ACALE can treat both Pylorus ligated and Aspirin-induced gastric ulcers. So, ACALE should be evaluated further and developed for future use as antiulcer drug.

Keywords: Side effects, ligation, gastric ulcer, antisecretory, flavonoids

Cite this Article

D. Santhi Krupa, Kusuma V., Sushma Reddy, Sofia Begum, Siresha K., Pooja Neelima, Padmalatha K. Evaluation of Antiulcer Activity of Allamanda cathartica Aqueous Leaf Extract in Experimental Rat Models. Research & Reviews: A Journal of Drug Design & Discovery. 2020; 7(1): 24–31p.