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A Review on Impact of DUE (Drug Utilization Evaluation) in Promotion of Rational Drug Prescribing in India

Umme Kulsum, Mekkanti Manasa Rekha, Rinku Mathappan


In recent years drug utilization studies have become a potential tool to be used in the evaluation of health systems. On the process of drug utilization studies focus on factors related to prescribing, dispensing, administering and taking of medication, and its associated events. Drug utilization data are available from databases- computerized or otherwise. From these databases different types of information, qualitative or quantitative or referring to a particular population are available. for collecting information on drug utilization Patient files and computer registries are widely used as instruments. depending upon the timing of data collection Prospective, Concurrent or Retrospective Drug Utilization studies may be used. Importance of drug utilization studies in pharmacoepidemiology has been increasing due to their close association to other areas like- public health, pharmacovigilance, Pharmacoeconomics and pharmacogenetics. This review article highlights various aspects, cycle, steps, need, scope, types, future perspectives.


databases, drug utilization, pharmacoeconomics, pharmacoepidemiology, pharmacogenetics

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Sjoqvist F, Birkett D. Drug Utilization. In: Bramley DW editor. Introduction to Drug Utilization Research. (WHO booklet) New York: WHO office of publications; 2003. P.76-84.

WHO Expert Committee. The Selection of Essential Drugs, Technical Report Series no. 615. Geneva: World Health Organization, 1977.

Einarson T. Pharmcoepidemiology. In: Parthasarathi G, Hansen KN, Nahata MC, editors. A Text book of Clinical Pharmacy Practice- essential concepts and skills. 1st ed., Hyderabad: Universities Press (India) Limited; 2008. p.405-23.

Laporte JR, Porta M, Capella D. Drug utilization studies: A tool for determining the effectiveness of drug use. Br J ClinPharmac 1983; 16(3):301-04.

Andersen M. Is it possible to measure prescribing quality using only prescription data? Basic Clin Pharmacol Toxicol 2006; 98(3):314-19.

Wettermark B, Hammar N, Michael FC, Leimanis A, Otterblad OP, Bergman U, et al. The new Swedish Prescribed Drug Registeropportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf 2007; 16(7):72635.

Moore TJ, Cohen MR, Furberg CD. Serious adverse drug events reported to the Food and Drug Administration. Arch Intern Med 2007; 167(16):1752-59.

Baum C, Kennedy DL, Forbes MB, Jones JK. Drug use and expenditures in 1982. JAMA 1985; 253(3):382-86.

Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. Lancet 2001; 357(9261):1851-53.

Rosholm JU, Gram LF, Isacsson G, Hallas J, Bergman U. Changes in the pattern of antidepressant use upon the introduction of the new antidepressants: a prescription database study. Eur J ClinPharmacol 1997; 52(3):205-09.

Strom BL. Pharmacoepidemiology. 4th ed. Chichester, England:John Wiley & Sons, Ltd 2005.

Scheckler WE, Bennett JV. Antibiotic usage in seven community hospitals. JAMA 1970; 213(2):264-67.

Bergman U, Elmes P, Halse M, Halvorsen T, Hood H, Lunde PK, et al. The measurement of drug consumption- Drugs for diabetes in Northern Ireland, Norway and Sweden. Eur J ClinPharmacol 1975; 8(2):83-89.

Boethius G, Wiman F. Recording of drug prescriptions in the country of Sweden. Methodological aspects. Eur J Clin Pharmacol 1977; 12(1):31-35.

Bergman U, Andersen M, Vaccheri A, Bjerrum L, Wettermark B, Montanaro N. Deviations from evidence-based prescribing of nonsteroidal anti-inflammatory drugs in three European regions. Eur J ClinPharmacol 2000; 56(3):269-72.

Lunde PK, Baksaas I. Epidemiology of drug utilization- basic concepts and methodology. Acta Med ScandSuppl 1988; 721:7-11.

Costa J, Rosa MM, Ferreira JJ, Sampaio C, VazCarneiro A. Cardiac effects of acute poisoning with tricyclic antidepressants: systematic review of the literature. Part I. Rev Port Cardiol 2001; 20(6):671-78.

Naqvi SH, Dunkle LM, Timmerman KJ, Reichley RM, Stanley DL, O’Connor D. Antibiotic usage in a pediatric medical center. JAMA 1979; 242:1981-84.

Shapiro M, Townsend TR, Rosner B, Kass EH. Use of antimicrobial drugs in general hospitals. II. Analysis of patterns of use. J Infect Dis 1979; 139(6):698-706.

Castle M, Wilfert CM, Cate TR, Osterhout S. Antibiotic use at Duke University Medical Center. JAMA 1977; 237:2819-22.

Townsend TR, Shapiro M, Rosner B, Kass EH. Use of antimicrobial drugs in general hospitals: IV. Infants and children. Pediatrics 1979; 64(5):573-78.

Hartz I, Sakshaug S, Furu K, Engeland A, Eggen A, Njolstad I, et al. Aspects of statin prescribing in Norwegian countries with high, average and low statin consumption – an individual-level prescription database study. BMC ClinPharmacol 2007; 7:14.

Duarte RF, Cabrita J. Using a pharmaco-epidemiological approach to estimate diabetes type 2 prevalence in Portugal. Pharmacoepidemiol Drug Saf 2006; 15(4):269-74.

Neutel CI, Walop W. Comparing two different approaches to measuring drug use within the same survey. Chronic Dis Can 2000; 21(4):15056.

Cabrita J, Ferreira H, Iglesias P, Baptista T, Rocha E, Lopes da Silva A, et al. Patterns and determinants of psychoactive drug use in Lisbon University students-a population-based study. Pharm World Sci 2004; 26(2):79-82.

Rocha O, Lunet N, Costa L, Barros H. Osteoporosis treatment in Portugal: trends and geographical variation. Acta Med Port 2006; 19(5):37380.

de Oliveira MS, Soares MA, Foppe van Mil JW, Cabrita J. Inappropriate drug use by Portuguese elderly outpatients--effect of the Beers criteria update. Pharm World Sci 2006; 28(5):296-301.

Marques VP, Dias CM. Hypnotic consumption in the Portuguese population: data from the National Health Survey 1998-1999. Pharmacoepidemiol Drug Saf 2006; 15(1):63-69.

Psaty BM, Lee M, Savage PJ, Rutan GH, German PS, Lyles M. Assessing the use of medications in the elderly: methods and initial experience in the Cardiovascular Health Study. The Cardiovascular Health Study Collaborative Research Group. J ClinEpidemiol 1992; 45(6):683-92.

Johnson RE, Vollmer WM. Comparing sources of drug data about the elderly. J Am GeriatrSoc 1991; 39(11):1079-84.

Lau HS, de Boer A, Beuning KS, Porsius A. Validation of pharmacy records in drug exposure assessment. J ClinEpidemiol 1997; 50(5):61925.

Klungel OH, de Boer A, Paes AH, Herings RM, Seidell JC, Bakker A. Influence of question structure on the recall of self-reported drug use. J ClinEpidemiol 2000; 53(3):273-77.

Van den Brandt PA, Petri H, Dorant E, Goldbohm RA, Van de Crommert S. Comparison of questionnaire information and pharmacy data on drug use. Pharm WeekblSci 1991; 13(2):91-96.

West SL, Savitz DA, Koch G, Strom BL, Guess HA, Hartzema A. Recall accuracy for prescription medications: self-report compared with database information. Am J Epidemiol 1995; 142(10):1103-12.

Goodman MT, Nomura AM, Wilkens LR, Kolonel LN. Agreement between interview information and physician records on history of menopausal estrogen use. Am J Epidemiol 1990; 131(5):815-25.


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