Open Access Open Access  Restricted Access Subscription or Fee Access

A Review on Anti-Inflammatory Activity of Benzthiazole Derivatives

D. Ravi Sankar Reddy, A. Naga Divya, Pranav Chand Tadikonda


Benzothiazoles are an important biologically active heterocyclic compounds which contain six membered benzene rings fused with five membered thiazole rings at 1,4 positions. They possess various biological activities like Anti-microbial, Anti-fungal, Anthelmintic, Antioxidant and Anti-inflammatory activities. Benzothiazoles nucleus is believed to produce it’s Anti-inflammatory activity either by inhibiting Beta-2 receptors of Bradykinin or by inhibiting cox₂ enzymes (cyclooxygenase). The present review focuses on some methods of benzothiazoles synthesis and its Anti-inflammatory activity.


Benzothiazoles, Anti-microbial, Anti-fungal, Anthelmintic, Antioxidant, Anti-inflammatory, Bradykinin, Cyclooxygenase.

Full Text:



Xiang Gao, Jiao Liu; Xin Zuo, Xinyue Feng; Ying Gao,” Recent advances in Synthesis of Benzothiazole Compounds Related to Green chemistry”: A review. MdpiJ.2020,5, (25),1675.

Prajapati, N.P.; Vekariya, R.H.; Borad, M.A.; Patel, H.D. “Recent advances in the synthesis of 2-substituted benzothiazoles”: A review. RSC Adv. 2014, 4, 60176–60208.

Batista, R.M Costa, S.P.; Raposo, M.M.M. “Synthesis of new fluorescent 2-(2’,2” bithienyl)1, 3-benzothiazoles”. Tetrahedron Lett. 2004, 45, 2825–2828.

Guo, H.Y; Li, J.C; Shang, Y.L.” A simple and efficient synthesis of benzothiazoles catalyzed by H₂O₂/HCl”.Chin. Chem.Lett.2009,20,1408-1410.

Maphupha, M.; Juma, W.P.; Koning, C.B.; Brady, D.” A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles”. RSC. Adv. 2018, 8, 39496–39510.

Ye, L.; Chen, J.; Mao, P.; Mao, Z.; Zhang, X.; Yan, M.” Visible-light-promoted synthesis of benzothiazoles from 2-aminothiophenols and aldehydes”. Tetrahedron Lett. 2017, 58, 874–876.

Merroun, Y.; Chehab, S.; Ghailane, T.; Akhazzane, M.; Souizi1, A.; Ghailane, R.” Preparation of tin-modified mono-ammonium phosphate fertilizer and its application as heterogeneous catalyst in the benzimidazoles and benzothiazoles synthesis”. Reac Kine. Mech Cat. 2019, 126, 249–264.

Kumar, A.; Maurya, R.A.; Ahmad, P. ‘Diversity oriented synthesis of benzimidazole and benzoxa/(thia) zole libraries through polymer-supported hypervalent iodine reagent”. J. Combin. Chem. 2009, 11, 198–201.

Praveen, C.; Nandakumar, A.; Dheenkumar, P.; Muralidharan, D.; Perumal, P. “Microwave-assisted one-pot synthesis of benzothiazole and benzoxazole libraries as analgesic agents”. J. Chem. Sci. 2012, 124, 609–624.

Bhat, R.; Karhale, S.; Arde, S.; Helavi, V. “Acacia concinna pod catalyzed synthesis of 2-arylbenzothia/(oxa) zole derivatives”. Iran. J. Catal. 2019, 9, 173–179.

Liao, Y.; Qi, H.; Chen, S.; Jiang, P.; Zhou, W.; Deng, G.P.” Efficient 2-Aryl Benzothiazole Formation from Aryl Ketones and 2-Aminobenzenethiols under Metal-Free Conditions” Org. Lett. 2012, 14, 6004–6007.

Bose, D.S.; Idrees, M. “Hypervalent Iodine Mediated Intramolecular Cyclization of Thioformanilides: Expeditious Approach to 2-Substituted Benzothiazoles”. J. Org. Chem. 2006, 71, 8261–8263.

Sukhbir L. Khokra, Kanika Arora; Heena Mehta, Ajay Aggarwal; Manish Yadav, “Common methods to synthesize Benzothiazole derivatives and their medicinal significance”: A review. IJPSR, 2011: vol 2 (6): 1356–1377.

Shaheen Sulthana, Pandian;” A review on Indole and Benzothiazole derivatives its importance “. jddt.2019; 9 (1-s):505–509.

Xian-Jing Zheng, Chun-ShiLi; Ming-Yuecui, Wen Song, Xue-Qian Bai, Cheng-Wu Liang; Hui-Yan Wang; Tian-Yizhang.” Synthesis, Biological evaluation of Benzothiazole derivatives bearing 1,3,4-Oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents”., 2020; 127237.

Gnanavel Sadhasivam, Kannan Kulanthai; “Synthesis, characterization, and evaluation of anti-inflammatory activity of new benzothiazole derivatives”. J.Chem.Pharm.2015; Res 8, 425–431.

David Izuchukwu Ugwu, Uchechukwu Christopher Okoro; Pius Onyeoziri Ukoha; Astha Gupta& Okafor.” Novel anti-inflammatory and analgesic agents: Synthesis, molecular docking and in vivo studies”. J Enzyme Inhib Med Chem.2018 Dec; 33 (1): 405–415.

Ahmed Kamal, Mohammed Ali Hussaini Syed; Shaheer Malik Mohammed. “Therapeutic potential of benzothiazoles”: a patent review. Expert Opin Ther Pat.2015 Mar; 25 (3): 335–49.

Eman M.H. Abbas. Kamelia M. Amin. Wageeh S. El-Hamouly. Dina H. Dawood. Mohammed. M. Abdalla.” Synthesis, anti-inflammatory and antinociceptive activity of some novel benzothiazole derivatives”. Res Chem.Intermed, 2015, 41 (4): 2537–2555.

Abhay Kumar Verma, Alex Martin, Arun Kumar Singh;” Synthesis, Characterization and evaluation of anti-inflammatory and Analgesic activity of Benzothiazole derivatives”. Indian.J.Pharm.Biol.Res. 2014; 2 (3); 84–89.

Anuradha Doma, Ravindra Kulkarni, Achaiah Garlapati; PR Krishna.” Synthesis and anti-inflammatory activity of novel pyrimidino benzothiazole amine derivatives”. Pharmacophore. 2015; 5 (2), 331–342.

Ruhi Ali, Nadeem Siddiqui;” Biological Aspects of Emerging Benzothiazoles”: A Short Review. J.of chem;2013. Available online at:

Deshmukh Vinayak Kashinath, Yadav Mukesh Rajmani, Chaudhari Sanjay Ravindra. “Synthesis and Anti-inflammatory activity of substituted pyrimido[2,1-b] [1,3] benzothiazole derivatives.” An.Int.Jour. 2013, 1 (6), 574–578.

Manish Srivastav, MD Salahuddin, SM Shantakumar. “Synthesis and Anti-inflammatory Activity of Some Novel 3-(6-Substituted-1, 3-benzothiazole-2-yl)-2-[{(4-substituted phenyl) amino}methyl] quinazolines-4(3H)-ones”. E-Journal of. Chem. 2009; 6 (4); 1055–1062.

P. Venkatesh, S.N. Pandeya, “ Synthesis, Characterization and Anti-inflammatory activity of some 2-Amino Benzothiazole derivatives “.Int.J.of.Chem.Tech.Research.2009;vol(1); 1354–1358.



  • There are currently no refbacks.

Copyright (c) 2022 Research & Reviews: A Journal of Drug Formulation, Development and Production