Synthesis and Biological Evaluation of Mannose Thiazolidinones

Authors

  • Avula Srinivas Associate Professor Department of Chemistry Vaagdevi Degree & PG College Kishanpura Warangal Telangana India 506001
  • Md Aleempasha Lecturer Department of chemistry, Vivekananda Institute of Technology & Science, Karimnagar Telangana, India 505001.
  • V Sudhaker Reddy Lecturer Department of chemistry, Vivekananda Institute of Technology & Science, Karimnagar Telangana, India 505001.
  • S Srinivas Lecturer Department of chemistry, Vivekananda Institute of Technology & Science, Karimnagar Telangana, India 505001.

DOI:

https://doi.org/10.37591/rrjodfdp.v5i2.117

Abstract

In a one pot procedure, a series of novel mannose thiazolidinone derivatives 4a–g and 5a–g were prepared by condensation of (3aS, 4S, 6S, 6aS)-6-methoxy-2,2-dimethyltetrahydrofuro [3,4-d][1,3]dioxole-4-carbaldehyde-3 with mercapto acids and primary amines in presence of ZnCl2 under both micro wave irradiation and conventional heating conditions. Compound-3 was prepared from Methyl di acetone D-Mannose with primary acetonide deprotection and with oxidative cleavage. Characterization of new compounds has been done by means of IR, NMR, MS and elemental analysis. The nematicidal and anti-bacterial activity of the compounds has also been evaluated.

 

Keywords: D-mannose, thiazolidinones, microwave assisted synthesis, antimicrobial and nematicidal activity

 

Cite this Article

Avula Srinivas, Md Aleempasha, Sudhaker Reddy V, et al. Synthesis and Biological Evaluation of Mannose Thiazolidinones. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2018; 5(2): 38–46p.

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Published

2018-10-31

Issue

Vol. 5 No. 2 (2018)

Section

Research Article

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