Preparation and Characterization of Solid Dispersion of Tenoxicam

Authors

  • Mudit Dixit Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE University, Mangalore, Karnataka, India
  • R. Narayana Charyulu Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE University, Mangalore, Karnataka, India
  • Amit Patil Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE University, Mangalore, Karnataka, India
  • C.S. Shastry Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE University, Mangalore, Karnataka, India

DOI:

https://doi.org/10.37591/rrjodfdp.v2i1.323

Abstract

The aim of the present study was to prepare solid dispersions of a poorly water-soluble drug Tenoxicam in Polyvinylpyrrolidone (PVP), prepared by spray-drying techniques. The physicochemical properties of the solid dispersion and drug-polymer interactions were characterized by DSC, FT-IR, XRD and SEM. Tenoxicam was found amorphously dispersed in solid dispersion systems with the drug to polymer weight ratio of 1:3. Dissolution profile of the prepared solid dispersion was compared with commercial sample. The solubility of prepared solid dispersion exhibited increases in solubility and dissolution than the commercial Tenoxicam.

 

Keywords: Spray Drying, Solid Dispersion, Tenoxicam, Polyvinylpyrrolidone, Solubility, Dissolution

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Published

2019-02-26

Issue

Vol. 2 No. 1 (2015)

Section

Research Article

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