Formulation and Evaluation of Hybrid Polymer Films using Metformin as Model Drug

Abstract

The present work was to formulate transdermal films which can produce a constant and prolonged release of drug using Chitosan and polyethylene oxide. In the present study high molecular weight Chitosan (300 K) and Polyethylene oxide (600 K) were used.initially, pre-formulation studies were performed to check the solubility of drug and polymers. A suitable method was developed for the estimation of absorption maxima of the drug by UV double beam spectrophotometer.Transdermal polymeric films of Metformin are formulated using different concentrations and proportions of polymers keeping the drug concentration constant. Nine formulations were prepared by varying concentrations and molecular weight of Chitosan and Polyethylene oxide. Evaluation tests were performed and invitro permeation studies were carried out for all the films using phosphate buffer pH 7. From invitro permeation studies, series 2 formulations showed better drug release compared to remaining films.

Keywords: Transdermal films, Metformin, chitosan, polyethylene oxide

Cite this Article

T. Swetha, Taher Patel, Bhavani Shankar et al. Formulation and Evaluation of Hybrid Polymer Films Using Metformin as Model Drug. Research & Reviews: A Journal of Drug Formulation, Development and Production. 2018; 5(1): 1–15p.