Current Trends about Transfersomes: Formulations, Applications and Pharmacological Interventions.

Moumita . Barman, Anuj . Tomar, Monika Singh, Rosaline Mishra

Abstract


Transfersomes are one of the novel targeted drug delivery system which includes hydrophilic molecules. Transfersomes are a type of liposomes which consists of phosphodidylcholine and an edge activator.  The elastic characteristics of Transfersomes enabling it to bend and penetrate through tiny holes that is much smaller than their own size. Transfersomes has various advantages like good solubility, greater bioavailability, and better penetration through the stratum cornea through intracellular route or transcellular route. Transfersomes are better than other micelle solution because of their flexible nature and the presence of water filled core. There are various methods to formulate Transfersomes like thin film hydration technique, modified hand shaking method, homogenization method and centrifugation method. Transfersomes can be evaluated through vesicle size distribution, zeta potential, entrapment efficiency, drug content, degree of deformity, ability to penetrate and stability studies. Its composition makes it safer & more effective than others. Medication release can also be regulated in this method of administration in accordance with the needs.

Full Text:

PDF

References


Sachan R., Parashar T, Vishal Singh S., Singh G., Tyagi S., Pateal C., Gupta A., “Transfersomes: A Novel Tool For Transdermal Drug Delivery System” International Journal of research and Development in Pharmacy and Life Sciences, 2013; 2(2): 309- 316.

Kombath R.V., Kumar MS, Anbazhagan S., Sandhya S., Saikumar P., Reddy T.R., Banji D. “Critical Issues Related To Transfersomes – Novel Vesicular System” Acta Sci. Pol., Technol. Aliment. 2012; 11(1): 67-82.

Jadupati, M.; Kumar, N.A. Transferosome: An opportunistic carrier for transdermal drug delivery system. Int. Res. J. Pharm. 2012, 3, 35–38.

Jain, A.K.; Kumar, F. Transfersomes: Ultradeformable vesicles for transdermal drug delivery. Asian J. Biomater. Res. 2017, 3, 1–13.

Rajan, R.; Jose, S.; Mukund, V.P.B.; Vasudevan, D.T. Transferosomes—A vesicular transdermal delivery system for enhanced drug permeation. J. Adv. Pharm. Technol. Res. 2011, 2, 138–143.

Elsayed M.M., Abdallah O.Y., Naggar V.F., and Khalafallah N.M: Deformable liposomes and ethosomes as carriers for skin delivery of ketotifen. Pharmazie 2007; 62: 133-137

S Saraf: Transferosomes, an overview. Pharmaceutical Reviews 2007; 5:6.

Cristina Dinu Pirvu, Cristina Hlevca, Alina ortan, Razvan Prisada: Elastic vesicles as drugs carriers through the skin. Farmacia 2010; 58(2) : 128

Elsayed M.M., Abdallah O.Y., Naggar V.F., and Khalafallah N.M: Deformable liposomes and ethosomes as carriers for skin delivery of ketotifen. Pharmazie 2007; 62: 133-137.

Kaushik A,Dwivedi A, Sunda M,Transfersomes: The Drug loaded ultradeformable vesicles for Transdermal Delivery,International Research Journal of Pharmacy,2011 2(11), 40-42.

Sheo DM, Shweta A, Vijay KT, Ram CD, Aklavya S, Ghanshyam M, “Enhanced Transdermal delivery of Indinavir Sulfate via transfersomes”, Pharmacie Globale (IJCP), 2010, 1 (06), 1-7.

. Kumar A, Pathak K, Bali V: Ultra–adaptable Nanovesicular Systems: A carrier for systemic delivery of therapeutic agents, Drug Discovery Today, 2012(17), 21-22.

Walve J.R, Bakliwal S.R, Rane B.R, Pawar S.P, Transfersomes: A Surrogated Carrier For Transdermal Drug Delivery System, 2011, 2(1).204- 213.

Parashar B, Kaur A, Gupta N, Singh B,Maurya B, Yadav V, Transfersomes-An approach for Vesicular Drug Delivery System 2012, Vol 2(2), 86- 91.

Bhardwaj V , Shukla V, Singh A, Malviya R , Sharma P.K, Transfersomes ultra flexible vesicles for transdermal delivery, Indian Journal Of Pharmaceutical Sciences and Research, (2010), Vol 1(3),12-19.

Cevc G, Grbauer D, Schatzlein A, Blume G. Ultraflexible vesicles, transferosomes, have an extremely low pore penetration resistance ant transport therapeutic amounts of insulin across the intact mammalian skin. Biochem Biophys Act. 1998. (201-215)

Paul, A, Cevec G. Non-invasive Administration of Protein Antigens. Epicutaneous with Bovin Serum Albumine, Vaccine Research, 1998.(145- 164).

Charge frustrated models of amphiphilic mixtures for the assembly of extended surfaces and micelles by Woo HJ, Carraro C, and Chandler. 1996; 104:183–191 in Faraday Discuss.

Zhdanov RI, Podobed OV, and Vlassov VV are in position 27. Lipoplexes, cationic lipid- DNA complexes used in gene therapy and transfer. 2002; 58:53 in Bioelectrochemistry.

P Strittmatter and H G Enoch. 1000-A-diameter, single-bilayer phospholipid vesicles: formation and characteristics. 1978's Techniques Enzymol. 52: 188–193.

Schatzlein and Cevc, 1998 & Schatzlein and Cevc, 2005.

Irfan M, Verma S, Ram A. 2012. Preparation and characterization of ibuprofen loaded transferosomes as a novel carrier for transdermal drug delivery system. Asian Journal of Pharmaceutical and Clinical Research, (5):162-165.

Cevc G, Blume G. 2001. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultra-deformable drug carriers. Transfersomes Biochem Biophys Acta, (1514):191-205.

G. Cevc. Isothermal lipid phase. Lipid Transitions: Chemistry and Physics, 1991; 57:293- 299.

A. Schatzlein and G. Cevc. Skin penetration by phospholipid vesicles, Transfersomes as visualised by Confocal Scanning Laser Microscopy, in characterisation, metabolism, and potential biological applications. Champaign, 1995; 191-209; AOCS Press.

Shailendra Saraf, Chanchal Deep Kaur, Gunjan Jeswani, and Swarnlata Saraf. Creation of an innovative herbal cosmetic cream using transfersomes filled with Curcuma longa extract for anti-wrinkle properties. 2011; 5(8):1054-1062 in African J Pharm Pharmacol.

N. k jain. Advances in Controlled and Novel Drug Delivery. CBS Publishers and Distributers First edition 2001. New Delhi, 426-451. 28. Surfactant impacts on lipid-based vesicles properties: a review by Bnyan, Khan, Ehtezazi, Saleem, Gordon, S., Neill, and Roberts. J. Pharm. Sci., 107, 1237–1246 (2018).

Using ultradeformable carriers for transdermal medication delivery of insulin, Cevc, G. Clinical Pharmacology, 42, 461-474,

A collaborative strategy for treating acne vulgaris: Vasanth, S., Dubey, A., Ravi, G.S., Lewis, S.A., Ghate, V.M., El-Zahaby, S.A., and Hebbar. Development and study of vitamin C-enriched adapalene-loaded transfersome gel. 2020, 21, 61, AAPS Pharm. Sci. Tech.

Design, optimisation, and characterisation of a transfersomal gel employing miconazole nitrate for the treatment of candida skin infections. Qushawy, M.; Nasr, A.; Abd- Alhaseeb, M.; Swidan, S. Pharmaceuticals 10, 26 (2018).2003.

The authors are El Zaafarany, G.M., Awad, G.A.S., Holayel, S.M., and Mortada, N. Edge activators and surface charge play a part in the development of ultradeformable vesicles with improved skin absorption. 164–172 in Int. J. Pharm. 2010, 397.

Penetration boosters: Williams, A.C. and Barry, B.W. 2004. Advanced Drug Delivery Review, 56, 603-618.

Elsayed, I.; Shamma, R.N. Buspirone HCl transfersomal lyophilized gel: formulation, assessment, and statistical optimisation. 2013, 23, 244–254 J. Liposome Res. .

Jain, S.K., Jain, P., Jain, N.K., and Umamaheshwari, R.B. Transfersomes: Development, characterisation, and performance assessment of a new vesicular carrier for improved transdermal administration. 2003, 29, 1013–1026; Drug Dev. Ind. Pharm.

Synthesis and characterisation of ivabradine HCl transfersomes for increased transdermal distribution by Balata, G.F., Faisal, M.M., Elghamry, H.A., and Sabry, S.A. 2020, 60, 101921. J. Drug Deliv. Sci. Technol.

Banala, N.; Youssef, A.A.A.; Mohammed, R.P.; Dudhipala, N. Aceclofenac loaded transfersomes gel development: lipid and edge activator concentration effects on in vitro and ex vivo skin permeability. 2020, 46, 1–28, Drug Dev. Ind. Pharm.

Prodrug techniques to increase drug percutaneous absorption, N'Da, D.D. Molecules 19, 20780–20807 (2014).

Cevc G., Vierl U. Nanotechnology and the transdermal route: A state of the art review and critical appraisal. J Control Release. 2010; 141(3):277-299.

Mitragotri S., Anissimov YG., Bunge AL., Frasch HF., Guy RH., Hadgraft J., Kasting GB., Lane ME., Roberts MS. Mathematical models of skin permeability: an overview. Int J Pharm. 2011; 418(1):115-129.

Scheuplein RJ. Permeability of the Skin- Comprehensive Physiology: Handbook of Physiology, Reactions to Environmental Agents.2011; 26: 299-322.

Negi L M., Garg A K., Chauhan M., Ultradeformable Vesicles: Concept and Execution Pharma Times. 2009; 41(9):11–14.

Sudhakar CK., Upadhyay N., Verma A., Jain A., Charyulu RN., Jain S., Nanomedicine and Tissue Engineering, In editors by Thomas S., Grohens Y., Ninan M., Nanotechnology Applications for Tissue Engineering. William Andrew Publishing, Oxford, 2015; 1-19.

Ita K. Current status of ethosomes and elastic liposomes in dermal and transdermal drug delivery. Curr Pharm Des. 2016 Press Print

Jain S., Tiwary AK, Sapra B., Jain NK. Formulation and evaluation of ethosomes for transdermal delivery of lamivudine. AAPS PharmSciTech. 2007; 8(4):E111.

Sudhakar CK., Upadhyay N., Jain S., Charyulu RN., Ethosomes as Non-invasive Loom for Transdermal Drug Delivery In: Sebastian M., Ninan N., Haghi A.K. editors Nanomedicine and Drug Delivery. San Diego, Apple Academic Press.2012; 1:1-16.

Cevc G., Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochimicaet Biophysica Acta, 1992:1104:226- 232.

Cevc G., Schatzein A., Blume G. Transdermal drug carriers: Basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides. J Control Release. 1995:36:3-16

Duangjit S., Obata Y., Sano H., Onuki Y., Opanasopit P., Ngawhirunpat T., Miyoshi T., Kato S., Takayama K. Comparative study of novel ultradeformable liposomes: ethosomes, transfersomes and liposomes for enhancing skin permeation of meloxicam. Biol Pharm Bull. 2014; 37(2):239-247.

Cevc G., Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochim Biophys Acta 2001;1514:191-205

Zhang YT., Shen LN., Wu ZH., Zhao JH., Feng NP. Comparison of ethosomes and liposomes for skin delivery of psoralen for psoriasis therapy. Int J Pharm. 2014; 471(1- 2):449-452.

Touitou E., Dayan N., Bergelson L., Godin B., Eliaz M. Ethosomes-novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J ContrRel. 2000; 65: 403-418.

Sudhakar CK., Charyulu RN., Influence of Permeation enhancer on Ethosomes bearing Lamivudine for Transdermal Drug Delivery. Res J Recent Sci. 2014; 3(IVC-2014), 155- 160


Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Research & Reviews: A Journal of Pharmacology