Enhancement of Aqueous Solubility of Etoposide Using Solid Dispersion Technique

Abstract

Objective: The objective of present research work was to enhance the aqueous solubility of Etoposide using solid dispersion technique. Methods: Formulation of solid dispersion by using different polymers and their different ratio with the used of solid dispersion technique. Solid dispersion formulation F-1 to F-9 were prepared by using different type and different concentration of polymers  like PEG-6000, PEG-4000 poloxomer 407 and  ethanol respectively. Results: The solid dispersion formulation were within the acceptable limits and drug release rates of all prepared solid dispersion formulations were distinctly higher as compared to pure drug. F3 formulation shows higher solubility than other formulations. All the Preformulation parameters were evaluated such as organoleptic characterization of drug sample, melting point, pH, and identification of drug samples by using UV spectroscopy and FTIR analytical method, preparation of calibration curves, solubility studies of drug sample by qualitative and quantitative methods. They were further processed for solid state characterization such as DSC the results confirmed the transformation of native crystalline nature of drug to amorphous state. FTIR analysis also confirmed no drug-excipients interaction. Solid dispersion F3 formulation showed improved in vitro dissolution behaviour of etoposide over that of pure drug. Conclusion: From this study it was concluded that solid dispersion method is promising method for improvement of dissolution property of water insoluble drugs.

Keywords: Etoposide, Solid dispersion, Polyethylene glycol6000, Bioavailability

Cite this article

Rupali Partani, Madhavi Kasturi, Neelesh Malviya. Enhancement of Aqueous Solubility of Etoposide Using Solid Dispersion Technique. Research & Reviews: A Journal of Pharmacology. 2019; 9(1): 29–37p.