Glibenclamide Induced Linear Immunoglobulin: A Dermatosis (LAD)

Abstract

Linear immunoglobulin A dermatitis is a rare autoimmune sub epidermal blistering disorder characterised by continuous deposition of IgA in the basement membrane zone. The disease may be drug related (glibenclamide) or non-drug related (Haematological, rheumatological). This is a rare disease observed in dermatology (IP) department, RIMS, Kadapa. A 50 years old female patient presented lesions on the trunk and purpuric eruptions since 2 months along with oral ulceration and itching. She is a known diabetic since 10 years, and on regular medication with (T. metformin 500 mg+T. glibenclamide 5 mg) etc. The diagnosis was confirmed by histopathology and direct immunofluorescence. So it was confirmed that glibenclamide induced LAD and was reported as an ADR. Based up on the Naranjo’s scale, the assessment was found to be as definite ADR (≥9). The exact pathogenesis of drug induced LAD remains obscure. Further studies are needed to find the mechanism of glibenclamide inducing LAD.

Keywords: LAD, dermatosis, autoimmune disease

Cite this Article

Nrithya Kumar S, Pandu Varaprasad C, Anakha Thyag et al. Glibenclamide Induced Linear Immunoglobulin: A Dermatosis (LAD). Research & Reviews: A Journal of Pharmacology. 2016; 6(1): 1–3p.