A Chronological Review on Preclinical and Clinical Evaluation of Antimicrobial Sutures

Abstract

Incidence of various infections is increasing with increased number of surgeries. Widespread common surgery procedures are associated with a 1–11% risk of surgical site infections (SSIs) which occur when pathogenic organisms proliferate in surgical wounds, result in impede wound healing, cause separation of the wound edges (dehiscence), and increase the risk of abscess in deeper wound tissues. Surgical site infection increases morbidity and mortality of postoperative patients and require prolonged antibiotic as it may progress from local to systemic infection. Moreover, surgical site infections are commonly associated with prolonged hospital stays, re-admission and higher healthcare cost. Commonly used sutures can house microorganisms and be a source of adherence and colonization. Hence, sutures coated with antimicrobial agents were introduced to prevent microbial adherence and colonization of suture materials and still under development. In this review we will have a brief history of the evaluation studies conducted for efficacy of conventional sutures to antibacterial sutures.

Keywords: Surgical site infection, antimicrobial sutures, surgical sutures, antibacterial sutures

Cite this Article

Probin Kumar Roy, Lalhlenmwia H, Rajat Subhra Dutta, et al. A Chronological Review on Preclinical and Clinical Evaluation of Antimicrobial Sutures. Research & Reviews: A Journal of Pharmacology. 2016; 6(1):