Friendly and Efficient Synthesis of Chalcone Derivatives under Solvent-Free Condition

Abstract

A series of various chalcone derivatives were synthesized using solvent free technique by grinding different substituted benzaldehyde, acetophenone and NaOH pellets at room temperature, and same reactions were carried out under solvent condition (50% EtOH). The reaction time needed to synthesize desired chalcones was 15–45 min; and 13 h stirring in the presence of solvent. All compounds were identified by comparison of their melting points with that of the substrates; the new compounds (III_e–III_h) were identified by spectroscopic methods.

Keywords: Benzaldehyde, acetophenone, grinding, solvent-free, room temperature reaction, ethanol

Cite this Article

Ali Mohamad F. Friendly and Efficient Synthesis of Chalcone Derivatives under Solvent-Free Condition. Research & Reviews: A Journal of Pharmacology. 2016; 6(1): 17–24p.