Aurora Kinase: A Target for Cancer Therapy

Abstract

Aurora kinases are the enzymes that belong to the family of serine/threonine kinases. It consists of Aurora-A (AURK-A), Aurora-B (AURK-B) and Aurora-C (AURK-C), which are the essential kinases for cell division through mitosis regulation especially for the process of chromosomal segregation. Aurora kinases are involved in meiosis regulation along with the regulation of mitosis. Inhibition of Aurora kinase leads to neglected cell division. Various cancer studies generally deal with gene amplification or overexpression. From the literature review, it is clear that inhibiting Aurora kinase will increase the effect of chemotherapies. Hence from the past decades, Aurora kinase inhibitors were developed, and they are now in clinical trials; however, these inhibitors effectively fail to give the complete therapy for cancer. This review mainly focuses on the Aurora kinase inhibitors and Aurora kinase as a target for anticancer therapy.

Keywords: Aurora-A, Aurora-B, Aurora-C, Aurora kinases, Aurora kinases inhibitors, cancer therapy target, mitosis

Cite this Article

Pushpaveni C., Arun Kumar C., Visagaperumal D., Vineeth Chandy. Aurora Kinase: A Target for Cancer Therapy. Research & Reviews: A Journal of Pharmacology. 2019; 9(3): 10–17p.