Characterization and Evaluation of Different Extracts from the Leaf and Bark of Mussaenda glabrata Hutch.

Authors

  • Sadia Afreen Chowdhury Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh
  • Mahfujur Rahaman Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh
  • Nowshin Nowaz Rumzhum Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh

Abstract


β-sitosterol (1) was isolated from the crude extract of the leaf of Mussaenda glabrata Hutch. (Family: Rubiaceae). The petroleum ether, chloroform and methanol extracts of the leaf and bark were screened in vitro for cytotoxic and antimicrobial activities by brine shrimp lethality bioassay and disc diffusion method, respectively. The petroleum ether and methanol extracts of the bark showed potential cytotoxic activity (LC50: 2.51 µg/ml and 2.94 µg/ml, respectively), the petroleum ether extract of the leaf and chloroform extract of the bark showed moderate cytotoxicity (LC50: 4.56 µg/ml and 6.57 µg/ml, respectively) and mild cytotoxic activity was observed with chloroform and methanol extracts of the leaf of M. glabrata Hutch. (LC50: 12.22 µg/ml and 8.84 µg/ml, respectively) in comparison with the standard Vincristine sulphate (LC50: 0.34 µg/ml). Mild antimicrobial activity was observed from all the crude extracts.

 

Keywords: Mussaenda glabrata Hutch., Rubiaceae, β-sitosterol, cytotoxic activity, antimicrobial activity

 

Downloads

Published

2020-12-31

Issue

Vol. 7 No. 1 (2017)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.