A Review on Clinical Aspects of Sickle Cell Anaemia

Abstract

Sickle cell anaemia is a genetic disorder in which there is a change in 6th position of Hb chain, i.e. replacement of glutamic acid by valine in the Hb chain. This disease was discovered in 1910 in United States by Dr. James B. Herrick. This disease was 1st affected to a young man named Walter Clement Noel from the island of Grenada, a dental student studying in Chicago. This article mainly includes history of disease, genetics, complication and risks of sickle cell anaemia, diagnosis and also treatment of sickle cell anaemia in case of children.

Keywords: Anaemia, sickle cell anaemia, red blood cells