Anti-nociceptive Potential of Scurrula parasitica: An Unexploited Parasitic Plant

Authors

  • Nilesh Mahajan Padmavathi College of Pharmacy, Periyanahalli, Dharmapuri, Tamil Nadu, India
  • Parag Joshi Jubilant Drug Discovery Centre, Bangalore, Karnataka, India
  • Manish Kondawar Appasaheb Birnale College of Pharmacy, Sangali, Maharashtra, India
  • K. L. Senthil Kumar Padmavathi College of Pharmacy, Periyanahalli, Dharmapuri, Tamil Nadu, India
  • V. Vaidhyalingam K. K. College of Pharmacy, Gerugambakkam, Chennai, Tamil Nadu

Abstract

 

Scurrula parasitica (Loranthaceae) is an herbaceous growing shrub parasitic on Dendrophthoe falcata (Loranthaceae) which is itself parasitic on Mangifera indica (Anacardiaceae). Scurrula parasitica is distributed throughout the western ghat region of Maharashtra, some parts of Uttar Karnataka and Tamil Nadu. Genus Scurrula comprising of around 91 species, however, only S. ferruginea, S. atropurpurea, S. fusca have been investigated systematically. No such pharmacological and phytochemical data are available on the plant Scurrula parasitica. So, the main intention of the current study is to investigate the unexploited angiospermic parasite plant, Scurrula parasitica for its ethno medical claims as well as pharmacological activities based on chemotaxonomic tracing, in experimental animals. The dried methanol extract (SPM) of the whole plant of Scurrula parasitica L was studied for its analgesic activity using animal models such as- Acetic-acid-induced writhing test (chemical stimulation), Heat conduction method (thermal stimulation) in comparison with Diclofenac sodium as reference standards. The SPM was given in doses of 100, 200 and 400 mg/kg body weight in which dose 400 mg/kg given significant results in comparison with reference standard Diclofenac sodium. The study may conclude that some chemical entities transferred from host Dendrophthoe falcata to the parasite Scurrula parasitica are accountable for its anti-nociceptive potential.

 

Keywords: Scurrula parasitica, anti-nociceptive, writhing, heat-conduction

Downloads

Published

2021-01-07

Issue

Vol. 3 No. 1 (2013)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.