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Formulation and Evaluation of Momordica charantia by Direct Compression Method
Abstract
The Momordica charantia herbal tablet was prepared by direct compression method. Various excipients used for the preparation of herbal tablet are such as Momordica charantia, MCC, Methyl Cellulose, Starch, and Sodium Benzoate. The anti-diabetic activity of Momordica charantia is due to their active ingredient that is present in their fruit part includes charantin, insulin-like peptide, cucurbitane, glycosides, Momordic in and oleanolic acid. The final tablet undergoes through post evaluation parameters such as hardness test, disintegration, friability, and weight variation.
References
Kumar Shubham, Mittal Anu, Babu Dinesh, Mittal Amit. Herbal Medicines for Diabetes Management and its Secondary Complications. Curr Diabetes Rev. 2021; 17(4): 437–456.
WHO/NCD/NCS/99.2 Original: English Distr.: General. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications.
Pang GM, Li FX, Yan Y, Zhang Y, Kong LL, Zhu P, Wang KF, Zhang F, Liu B, Lu C. Herbal medicine in the treatment of patients with type 2 diabetes mellitus. Chin Med J (Engl). 2019 Jan 5; 132(1): 78–85.
He Q, Yang J, Zhang G, Chen D, Zhang M, Pan Z, Wang Z, Su L, Zeng J, Wang B, Wang H, Chen P. Sanhuang Jiangtang tablet protects type 2 diabetes osteoporosis via AKT-GSK3β-NFATc1 signaling pathway by integrating bioinformatics analysis and experimental validation. J Ethnopharmacol. 2021 Jun 12; 273: 113946.
Pharmapproach. (2021 May). Solid Dosage Forms: Tablets. [Online]. Available from https://www.pharmapproach.com/solid-dosage-forms-tablets/.
Mishra and Mishra. Development of Herbal Tablet Formulation: Systematic Approach. Altern Integr Med. 2019; 8(1): 1000275.
Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus. J Med Food. 2018 Jul; 21(7): 672–677.
Peter EL, Kasali FM, Deyno S, Mtewa A, Nagendrappa PB, Tolo CU, Ogwang PE, Sesaazi D. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019 Mar 1; 231: 311–324.
Patel D, Patel A, Solanki T. Formulation and evaluation of bilayer tablet by using melt granulation technique for treatment of diabetes mellitus. J Pharm Bioallied Sci. 2012 Mar; 4(Suppl 1): S37–9.
Walia, et al. Herbal Drugs with Anti-Diabetic Potential. J Drug Deliv Ther. 2021; 11(6): 248–256.
Sharma D, Singh M, Kumar D, Singh G. Formulation development and evaluation of fast disintegrating tablet of cetirizine hydrochloride: a novel drug delivery for pediatrics and geriatrics. J Pharm. 2014; 2014: 808167.
Tanaka R, Osotprasit S, Peerapattana J, Ashizawa K, Hattori Y, Otsuka M. Complete cocrystal formation during resonant acoustic wet granulation: Effect of granulation liquids. Pharmaceutics. 2021 Jan 4; 13(1): 56.
Bhat M, Kothiwale SK, Tirmale AR, Bhargava SY, Joshi BN. Antidiabetic properties of Azardiracta indica and Bougainvillea spectabilis: in vivo studies in murine diabetes model. Evid-Based Complement Altern Med. 2011 Jan 1; 2011: 561625.
Sharma D, Singh M, Kumar D, Singh G. Formulation development and evaluation of fast disintegrating tablet of cetirizine hydrochloride: a novel drug delivery for pediatrics and geriatrics. J Pharm. 2014; 2014: 808167.
Zhang D, Arunachalam K, Wang Y, Zhang Y, Yang J, Hein PP, Mon AM, Li J, Inta A, Yang X. Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar. Sci World J. 2021 Jan 1; 2021: 1424675.
Muñiz-Ramirez A, Perez RM, Garcia E, Garcia FE. Antidiabetic activity of Aloe vera leaves. Evid-Based Complement Altern Med. 2020 May 25; 2020: 6371201.
Muñiz-Ramirez A, Perez RM, Garcia E, Garcia FE. Antidiabetic activity of Aloe vera leaves. Evid-Based Complement Altern Med. 2020 May 25; 2020: 6371201.
Verma, et al. Diabetes Mellitus Treatment Using Herbal Drugs. Int J Phytomedicine. 2018; 10(1): 1–10.
Otunola GA, Afolayan AJ. A review of the antidiabetic activities of ginger. Ginger Cultivation and Its Antimicrobial and Pharmacological Potentials. InTech Open; 2019 Nov 27.
Jagetia GC. A review on the role of jamun, syzygium cumini skeels in the treatment of diabetes. Int J Complement Alt Med. 2018; 11(2): 91‒95.
Lanjewar Ameya, Sharma Devender, Godbole Mangesh, Burle Sushil. Formulation and evaluation of tablets containing poorly water soluble drug by madg method. World J Pharm Res. 2017; 6(3): 1523–1537.
Abhilash Rao S, Vijay Y, Deepthi T, Ch SL, Rani V, Rani S, Bhuvaneswara Reddy Y, Ram Swaroop P, Sai Laxmi V, Nikhil Chakravarthy K, Arun P. Anti diabetic effect of ethanolic extract of leaves of Ocimum sanctum in alloxan induced diabetes in rats. Int J Basic Clin Pharmacol. 2013; 2(5): 613–616.
Santoshkumar J, Manjunath S, Mariguddi DD, Kalashetty PG, Dass P, Manjunath C. Anti-diabetic effects of turmeric in alloxan induced diabetic rats. J Evol Med Dent Sci. 2013 Mar 18; 2(11): 1669–80.
Mohamed Nifras. Anti-diabetic Effect of Cinnamon. Scientific Literature Review – Presentation. 2017. 10.13140/RG.2.2.18940.44169.
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