Determination of Gastric Irritation Inducing Effect of Iron-Containing Unani Compound Formulations In Animals

Authors

  • Yousuf Saleem
  • Mohammad Rafi Thoker
  • Junaid Nazir Dandroo

Abstract

Abstract

Background: Iron is the most commonly used metal for human welfare on earth and also a vital element for sustenance of life.Iron deficiency is a common affliction of human beings all over the globe and presents as iron deficiency anaemia. Most effective and preferred treatment of iron deficiency is replenishment of iron by oral administration. Successful completion of treatment depends on tolerance of the prescribed drug by a patient. Oral administration of iron is notorious for gastrointestinal intolerance which ranges from minor complaints like nausea, vomiting, constipation, gastric discomfort, or pain due to minor mucosal erosions or frank ulcerations. Aim of the study: Sharbat Faulad is the drug of choice used in the Unani system of medicine for oral replenishment of iron. To study the gastrointestinal tolerance and its therapeutic suitability, gastric irritation inducing effect of Sharbat Faulad manufactured by three different leading Unani pharmaceutical companies in India was conducted on albino rats. Methodology: The study was conducted by Thuillier’s method. The animals were divided into 04 groups. Group I was administered Sharbat Faulad of Hamdard Laboratories, Delhi. Group II was given Sharbat Faulad of Rex Remedies, Delhi. Group III received Sharbat Faulad of Dawakhana Tibbiya College, AMU Aligarh. Group IV served as blank control and received 5ml distilled water. This treatment continued for 14 days and on the 15th day all animals of the test and control groups were sacrificed. The abdomen was opened to remove the stomachs for observation under high magnification. Results: The results revealed that no abnormal changes like congestion, effusion, erosion, etc. was seen in the stomachs of the animals. Conclusion: The preparations are safe with respect to gastric irritation-inducing liability as the ulcerogenic index calculated in animals was zero.

 

Keywords: Sharbat faulad, iron deficiency anaemia, oral iron replenishment, gastric irritation, ulcerogenic index

Citation: Yousuf Saleem, Mohammad Rafi Thoker, Junaid Nazir Dandroo. Determination of Gastric Irritation Inducing Effect of Iron-Containing Unani Compound Formulations In Animals. Research & Reviews: A Journal of Pharmacognosy. 2022; 9(3): 25–29p.

References

Vohora SB, Dobrowolski JW (1990): New horizons of health aspects of elements, Jamia Hamdard University, New Delhi.

Guyton and Hall (2020): Textbook of Medical Physiology, 14th ed., ELSEVIER; 14th Floor, Building No 10 B, DLF Cyber City, Phase – II, Gurgaon Haryana (India) 122027.

Park K (2021): Textbook of Preventive and Social Medicine, 26thEd., Banarsidas Bhanot Publishers, Jabalpur.

DeMaeyer E and Adiels-Tegman M (1985): The prevalence of anemia in the world, World Health Statistics Quarterly, 38.

Harrison (2022): Principles of Internal Medicine, 21st Ed., McGraw Hill Education (India) Private Limited, B-4, Sector-63, Dist. Gautam Budh Nagar, Noida – 201 301, UP.

Goodman &Gilman (2017): The pharmacological basis of therapeutics, 13thEd., McGraw-Hill, Inc., New York.

Laurence DR, Bennet PN, Brown MJ (2003): Clinical pharmacology, 9thEd., Churchill Livingstone, Edinburgh.

Thuiller J, Bassin P, Geffory F R and Godfroid J J (1968): Chemic et al Pharmacologic ela la colfezone chim, Therap., 3.

Turner R A (2009): Screening Methods in Pharmacology, Academic Press; New York.

Israr A A (1990): A scientific study of some Unani Drugs used in Waja-ul-Mafasil. Deptt. Of Ilmul Advia, AMU Aligarh.

Kalra BS, Shalini, Sonali Chaturvedi, Vandana Tayal, Usha Gupta (2009): Evaluation of gastric tolerability, antinociceptive and anti-inflammatory activity of combination NSAIDs in rats. Indian J Dent Res.2009, Oct-Dec; 20(4). {PMID: 20139563}.

Donald Ewing, Ava Brozovich, Ethan Burns (2019): Gastric siderosis and ulceration from intravenous iron supplementation manifesting as chronic upper gastrointestinal bleeding: A case report and review of the literature. Case Rep Gastrointest Med. Apr, 2019 {PMID: 31139476}

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Published

2023-02-07

Issue

Vol. 9 No. 3 (2022)

Section

Research Article

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