Anti-Inflammatory Activity of Pedalium Murex Leaves in Rats

Authors

  • Mohammad Altaf Shareef Research Scholar Department of Pharmacy Practice Pratishta Institute of Pharmaceutical Sciences, Suryapet, Hyderabad, Telangana
  • Qadrie Z L Research Scholar Department of Pharmacy Practice Pratishta Institute of Pharmaceutical Sciences, Suryapet, Hyderabad, Telangana
  • Suman A. Professor and Head Department of Pharmacology Pratishta Institute of Pharmaceutical Sciences Suryapeta, Telangana-508214, India.
  • Sai Teja D Research Scholar Department of Pharmacy Practice Pratishta Institute of Pharmaceutical Sciences, Suryapet, Hyderabad, Telangana
  • Ashok Kumar D. Professor and Head Department of Pharmacognosy Pratishta Institute of Pharmaceutical Sciences, Suryapeta, Telangana-508214, India
  • M. Nagavamsidhar Research Scholar Department of Pharmacy Practice Pratishta Institute of Pharmaceutical Sciences, Suryapet, Hyderabad, Telangana

Keywords:

Pedalium murex, methanol extract, Carrageenan, Dextran.

Abstract

Herbal drugs are being proved as effective as synthetic drugs with lesser side effects. Herbal medicines are in line with nature, with less hazardous reactions. Pedalium murexis traditionally used for the treatment of puerperal diseases, digestive tonics, ulcers, fevers, wounds and general debility. The aim of the present study is to evaluate the phytochemical and anti-inflammatory activities of methanolic extract of leaves of Pedalium murex Linn (Pedaliaceae) in rats. The leaves of Pedalium murex (L.) in methanol extract showed the presence of flavonoids, alkaloids, steroids, resins, saponins and proteins. The result of the anti-inflammatory effect of the methanolic extract of Pedalium murex (L.) (MEPM) on carrageenan-induced edema was a gradual increase in edema paw volume of rats in the control. The maximum inhibition of 19.43 and 29.68% in MEPM at the dose of 200 and 400 mg/kg respectively, showed after 3 h of treatment in carrageenan induced paw edema, whereas the standard drug indomethacin at the dose of 10 mg/kg showed 40.72% of inhibition. In dextran induced paw edema, MEPM at the doses of 200 and 400 mg/kg showed significant inhibition of 14.73 and 29.79%. Indomethacin showed 40.00% From the present study, it can be concluded that MEPMhas potential dose-dependent and anti-inflammatory effect and gives a solid scientific approach to the traditional uses of the plant Pedalium murex.

 

Keywords: Pedalium murex, methanol extract, carrageenan, dextran


Cite this Article

Mohammed Altaf S, Qadrie ZL, Suman A, et al. Anti-Inflammatory Activity of Pedalium Murex Leaves in Rats. Research & Reviews: A Journal of Pharmacognosy. 2018; 5(3): 1–4p.


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Published

2019-01-09

Issue

Vol. 5 No. 3 (2018)

Section

Research Article

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