Antidiabetic Property of Cucumis Sativus Aqueous Leaf Extracts in Alloxan Induced Type 2 Diabetic Rats

Abstract

Studies have proven the antidiabetic property of fruit, seeds and pulp of Cucumis sativus. Hence, to investigate the antidiabetic property of the leaf, the aqueous leaf extract of Cucumis sativus L. (Cucurbitaceae) was investigated on alloxan induced type 2 diabetic rats. Diabetes mellitus was induced with alloxan and different graded doses of the extracts were then administered to normal and experimental diabetic rats for 12 days. Evaluation was done in normal rats for fasting serum lipid profiles, plasma glucose levels, and changes in body weight while in diabetic rats, additionally liver glycogen levels and pancreatic TBARS levels were evaluated. Standard glibenclamide were then used for comparing all the diabetic groups. The results of our study support the claim of antidiabetic property of Curcumis sativus.

Keywords: Alloxan induced diabetes, antidiabetic effect, aqueous extract, cucurbitaceae, Cucumis sativus, oral glucose tolerance test

Cite this Article

Iswar Hazarika, Folitartha Roy, Ruhul Amin Haque. Antidiabetic property of Cucumis Sativus aqueous leaf extracts in alloxan induced type 2 diabetic rats. Research & Reviews: A Journal of Pharmacognosy. 2015; 2(3): 28–33p.