Antimicrobial Potential of Methanolic Extract of Barringtonia acutangula (L.) Gaertn Fruits

Authors

  • A. Mohanty Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India
  • C. Das Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India
  • G. Ghosh Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India
  • P.K. Sahu Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India

DOI:

https://doi.org/10.12300/rrjopc.v3i3.435

Abstract

 

Barringtonia acutangula is a middle-sized plant which is distributed in Meghalaya, Assam, West Bengal, Madhya Pradesh, Bihar and Odisha, used in treatment of various ailments. The present work has investigated the antimicrobial activity of methanol extract of Barringtonia acutangula fruit against six resistance bacterial strains such as Enterococcus faecalis, Staphylococcus aureus, Acinetobacter bumannii (Gram positive) and Citrobacter freundii, Enterobacter aerogenes, Escherichia coli (Gram negative). The antibacterial activity was evaluated by well-in agar assay. It was found that methanol extract of B. acutangula showed significant antibacterial activity against the test micro-organisms by disc diffusion and tube dilution methods. Further, the extract was found to be more effective against gram positive bacteria. Methanol fruit extract of B. acutangula showed minimum inhibitory concentration (MIC) ranges between 0.67 and 4.27 mg/ml and minimum bactericidal concentration (MBC) ranges between 1.51 and 9.63 mg/ml. The presence of carbohydrate, glycoside, saponins, flavonoids, alkaloids, tannins and phenolic compounds were ascertained on phytochemical screening of methanol extract of the fruit. The present work revealed that, phytochemical compounds present in fruit of this plant are principal sources for significant antibacterial activity. Further study is needed to access the development of novel formulation by taking fruit extract of B. acutangula and isolation of bioactive phytoconstituents.

 

Keywords: Barringtonia acutangula, phytochemical screening, anti-microbial activity

Cite this Article

Mohanty A, Das C, Ghosh G et al. Antimicrobial Potential of Methanolic Extract of Barringtonia acutangula (L.) Gaertn Fruits. Research & Reviews: A Journal of Pharmacognosy. 2016; 3(3): 13–18p.


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Published

2019-03-06

Issue

Vol. 3 No. 3 (2016)

Section

Research Article

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