Impact of Grape Seed Extract on Liver Function against Cadmium Chloride-Induced Toxicity

Abstract

The present study was designed to evaluate the antioxidant activities of grape seed and to benefit from the impact of grape seed on hepatotoxicity mediated by cadmium chloride (CdCl₂). Gas liquid chromatography (GC-MS) was used to assay the chemical profile. A total of 40 male rats (10 rats per group) were divided into four groups: (1) control group, (2) grape seed group: rats treated with grape seed extract (GSE) at a dose of 200 mg/kg body weight, (3) Category Cd: rats treated with CdCl₂ at a dose of 5 mg/kg body weight, (4) Cd category+Population of grape seeds group: 200 mg/kg body weight of GSE-treated rats, in addition to CdCl₂-treated rats for 90 days. At the end of the experiment, certain statistics were determined from blood samples, liver tissue and histological tests. The GC-MS results showed that a wide range of compounds appeared in the extract. Oxidative stress health effects of exposure to CdCl₂ has been observed to cause decrease in body and liver weight, glutathione (GSH) and catalase (CAT) levels, in addition to increasing the level of malonialdehyde (MAD). GSE has greatly decreased the biological changes caused by CdCl₂ in the blood and liver tissue (P < 0.05).

Keywords: cadmium chloride (CdCl₂), Gas liquid chromatography (GC-MS), grape seed extract (GSE), oxidative stress

Cite this Article

Hanaa M. Hassan, Hamadi A. Ismail, Hemdan M. Ibrahim, Magda E. Mahmoud. Impact of Grape Seed Extract on Liver Function Against Cadmium Chloride-Induced Toxicity. Research & Reviews: A Journal of Pharmacognosy. 2020; 7(3): 30–39p.