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Liposome and Its Method of Preparation: A Review

Khushboo Bhardwaj, Kamal Singh Bani

Abstract


Liposomes are spherical vesicles that self-assemble and range in size from 20 nm to 10 m. They can be used as drug carriers for lipophilic, hydrophilic, and amphiphilic medications. Lipophilic and amphiphilic drugs can be encapsulated inside the lipophilic bilayer, whereas hydrophilic drugs can be integrated into the aqueous heart. Many liposomal preparations are currently undergoing clinical trials, with some of them being accepted for clinical use. By altering the biodistribution of many drugs, liposomes improve their therapeutic value. Liposome formulations are a relatively new advancement in the area of drug delivery to the body's site of action. Liposomes are designed and manufactured based on the drug type. The characteristics of the membrane and the dissolving process influence drug delivery from liposomes. Liposomes can be used to make both lipid and water-soluble drug formulations. This analysis focuses on liposome preparation, process, forming mechanism, applications, and targeting.


Keywords


Liposome, Classification, Preparation method, Application, Limitation

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References


Sipai A, Vandana Y, Mamatha Y, Prasanth V. Liposomes: an overview. J Pharm Sci Innov. 2012;1:13-21.

Dwivedi Ag, Boda R. Preparation and Characteriztion of Liposomal Based Drug Delivery System for Effective Management of Cancer 2015.

Khandelwal K, Pachauri SD, Arya A, Pawar VK, Joshi T, Dwivedi P, et al. Improved oral bioavailability of novel antithrombotic S002-333 via chitosan coated liposomes: a pharmacokinetic assessment. RSC Advances. 2015;5(49):39168-76.

Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, et al. Liposome: classification, preparation, and applications. Nanoscale research letters. 2013;8(1):102.

Brgles M, Jurašin D, Sikirić MD, Frkanec R, Tomašić J. Entrapment of ovalbumin into liposomes—factors affecting entrapment efficiency, liposome size, and zeta potential. Journal of liposome research. 2008;18(3):235-48.

Kulkarni PR, Yadav JD, Vaidya KA. Liposomes: a novel drug delivery system. Int J Curr Pharm Res. 2011;3(2):10-8.

Gubernator, J. Active methods of drug loading into liposomes: Recent strategies for stable drug entrapment and increased in vivo activity. Expert Opin. Drug Deliv. 2011, 8, 565–580.

Zhao, Y.C.; May, J.P.; Chen, I.W.; Undzys, E.; Li, S.D. A Study of Liposomal Formulations to Improve the Delivery of Aquated Cisplatin to a Multidrug Resistant Tumor. Pharm. Res. 2015, 32, 3261–3268.

Bally, M.B.; Mayer, L.D.; Loughrey, H.; Redelmeier, T.; Madden, T.D.; Wong, K.; Harrigan, P.R.; Hope, M.J.; Cullis, P.R. Dopamine accumulation in large unilamellar vesicle systems induced by transmembrane ion gradients. Chem. Phys. Lipids 1988, 47, 97–107.

Mayer, L.D.; Bally, M.B.; Cullis, P.R. Uptake of Adriamycin into Large Unilamellar Vesicles in Response to a Ph Gradient. Biochim. Biophys. Acta 1986, 857, 123–126. Pharmaceutics 2019, 11, 465 11 of 12

Deamer, D.W.; Prince, R.C.; Crofts, A.R. The response of fluorescent amines to pH gradients across liposome membranes. Biochim. Biophys. Acta 1972, 274, 323–335.

Bhatt, P.; Lalani, R.; Vhora, I.; Patil, S.; Amrutiya, J.; Misra, A.; Mashru, R. Liposomes encapsulating native and cyclodextrin enclosed paclitaxel: Enhanced loading efficiency and its pharmacokinetic evaluation. Int. J. Pharm. 2018, 536, 95–107.

Sahil K, Premjeet S, Ajay B, Middha A, Bhawna K. Stealth liposomes: a review. Int J Res Ayurveda Pharm. 2011;2(5).

Brandl M. Liposomes as drug carriers: a technological approach. Biotechnology annual review. 2001;7:59-85.

Brown S, Khan DR. The treatment of breast cancer using liposome technology. Journal of drug delivery. 2012;2012.

Sharma G, Anabousi S, Ehrhardt C, Ravi Kumar M. Liposomes as targeted drug delivery systems in the treatment of breast cancer. Journal of drug targeting. 2006;14(5):301-10.

Chonn A, Cullis PR. Recent advances in liposomal drug-delivery systems. Current Opinion in Biotechnology. 1995;6(6):698-708.


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