Comparative Evaluation of Corneal Permeation of Indomethacin Using Different Vegetable Oil

Abstract

Topical administration of drugs is the most favoured route for management of ocular inflammation. About 90% of dose applied topically from such solutions is lost due to precorneal losses (nasolacrimal drainage) and tearing results in poor availability as contact time is less between drug and ocular tissue. An increased ocular contact time of the drug may be achieved by formulating the drug as an oil solution. In this study, invitro permeation of indomethacin from oil drops were studied in arachis, castor and linseed oil. Partition behaviour studies in each oil with and without benzyl alcohol were conducted and based on partition study a suitable oil was selected for further evaluation. Based on partition value of Indomethacin in each oil, comparatively partition in arachis oil with benzyl alcohol showed better results compared to castor and linseed oil with and without benzyl alcohol. Invitro studies of Indomethacin in arachis oil (both 0.5%w/v and 1%w/v) was performed. Increased permeation was obtained in 1%w/v Indomethacin drops in arachis oil with benzyl alcohol compared to 0.5%w/v Indomethacin drops in arachis oil with benzyl alcohol. The amount permeated was found to be maximum with Indomethacin 1%w/v (0.092 mg or 0.09%) solution in arachis oil than in 0.5%w/v (0.042 mg or 0.084%) and the addition of Benzyl alcohol to oil drops increases drug permeation due to an increased partitioning of the drug in the aqueous phase.