Flash Chromtography and Its Analytical Application: A Review

Authors

  • Bavkar Manasi M. 2nd year M.Pharmacy, Department of Quality Assurance Team, Alard College of Pharmacy, Marunji, Hinjewadi, Pune, India
  • Madhuri Shelar Assistant Professor, Department of Quality Assurance Team, Alard College of Pharmacy, Marunji, Hinjewadi, Pune, India
  • Ganesh Andhale Associate Professor, Head of Pharmaceutical Chemistry Department, Alard College of Pharmacy, Marunji, Hinjewadi, Pune, India
  • Jyoti Kadam Assistant Professor, Department of Quality Assurance Team, Alard College of Pharmacy, Marunji, Hinjewadi, Pune, India

Keywords:

Chromatography, compound, Eluent, Column, HPTLC, TLC.

Abstract

Different chromatography techniques such as TLC, HPTLC, HPLC etc. are mainly used for separation of mixture. The column chromatography was use in many laboratories for separation and purification of different components. The separation of components based on partitioning or adsorption of solute on stationary to purify the liquids and for reaction control in organic synthesis.Column chromatography is a time consuming process. Flash Chromatography is a development of novel preparative liquid chromatography in which mobile phase flows down by positive air pressure. It is a rapid form of preparative column chromatography based on an air pressure driven hybrid of medium and short column chromatography optimized for rapid separation of organic compound. It is a simple, fast, economic and flexible process.

References

Still WC, Kahn M, Mitra A. Rapid chromatographic technique for preparative separations with moderate resolution.J.Org.Chem.1978:43(14):2923–2925.

Roge A, Firke S, Kawde R, Sarje S, vadavalkar S. Breif review on flash chromatography. International journal of Pharmaceutical science & Research, 2011; 2(8);1930 1937.

Ayare P*, Khanvilkar V, Chalak N. Flash chromatography: Area and application. Pharmatutor, 2014; 2(5); 89–103.

William C. S, Hill D. C. General methods for flash chromatography using disposable column. Mol. Divers, 2009; 13(2); 247–252.

SkoogDA, Holler FJ, Crouch SR. Fundamental of Instrumental Analysis. India: Thomson Books/Cole Publication, 2007.

Bhusal R, Nahar D, Dalvi P. Review on Flash column chromatography, Indo American Journal of Pharmaceutical Research, 2017;7(01); 7353–7358.

Chaudhari H, Chaudhari F, Patel M, Pradhan P, Upadhyay U. Review on Flash Chromatography, International Journal of Pharmaceutical Development & Technology,2012; 2(2);80–84.

Dewick P, John Wiley & Sons, Inc., Hoboken, Medicinal natural products; a biosynthetic approach, New Jersey, 2009.

Discoveryscience.com

Buchi. Preparative Chromatography Solutions. Available online at: https://www.buchi.com/in-en/content/preparative-chromatography-solutions

Technical Bulletin.Input TLC Rf values. Available online at: http://yamazenusa.com/images/technical_bulletin_No44.pdf

Downloads

Published

2021-09-15

Issue

Vol. 12 No. 2 (2021)

Section

Review Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.