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AQUASOMES: A Vesicular, Self-assembled Ceramic Nano-particulate Drug Carrier

K. Samson, M. Varalakshmi, K. Prathima


Nano-biopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multi-functional nanoparticles, quantum dots, aquasomes, super-paramagnetic iron oxide crystals, and liposomes dendrimers. Aquasomes are considered as one of the most recently developed delivery systems for bioactive molecules like peptides, proteins, hormones, antigens and genes to specific sites. Aquasomes have a spherical shape and a particle size of 60–300 nm. These are three layered self-assembled nano-particulate carrier system. This three-layered structure has a polyhydroxy oligomer coated centre into which biochemically active molecules are adsorbed. Three types of core material are used to produce aquasomes; Tin oxide, Nano-crystalline carbon ceramics (diamonds) and Brushite (calcium phosphate dihydrate). Because of their high degree of order and structural regularity, ceramics are commonly used as core materials. Carbohydrate coating have aqueous environment and this protects active drug molecule from dehydration. There by it improves stability of active drug molecule. The current review provides an overview of the aquasomes as a promising tool for drug delivery. It includes brief introduction of aquasomes, self-assembling principles, composition of aquasomes, objectives, properties, advantages, methods of preparation, characterization study and therapeutic applications as a drug delivery system


Aquasomes, ceramics, self-assembled molecules, polyhydroxy oligomer, drug carrier, characterization, applications

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