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Sumatriptan Succinate Mucoadhesive Buccal Tablets: Formulation Design, Optimization and Evaluation

Tushar Dilip Sonawane, S.P. Pawar


The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical evaluation of compressed tablet was performed and found satisfactory. The optimized formulation F8 containing HPMC (Metolose SR 90SH-15000) and xanthan gum (1:2) and in vitro drug release study showed sustained drug released for 9 Hours. Optimization study was performed by using design of experiment (DoE). In vitro drug release study data revealed that combination of Metolose SR 90SH-15000 (30 mg) and Xanthan Gum (60 mg) along with diluent dibasic calcium phosphate (41 mg) shown desired drug release profile with sustained manner. The approach describes the efficiency of bioadhesive polymer to adhere the mucous lining and prolong the drug release. Backing layer of ethyl cellulose (EC) was used to provide unidirectional drug release. The in vitro release kinetics reveals that formulation follows Korsmeyer–Peppas model. Optimized formulation was stable for1 month accelerated stability condition at 40°C and 75% RH.


Migraine, buccal mucoadhesion, swelling index, release kinetics, QbD, bioadhesive

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Haranath C, Ahmed Khan KA, Reddy Surya Prakash C, Pradeep Kumar B, Veera V, Bhadrappa K. Formulation and in Vitro Evaluation of Mucoadhesive Buccal Tablet of Antimigrain Drug. Inventi Rapid: 2015; NDDS (4):1–10.

Shaik S, Himabindu S, Sathish D. Formulation and ex vivo evaluation of buccal tablets of Eletriptan hydrobromide. Am J Pharm Tech Res. 2012;2(3):919–30.

Fatima S, Panda N, Reddy VA, Fatima S. Buccal mucoadhesive tables of sumatriptan succinate for Treatment of Sustainable Migraine: design Formulation and in vitro Evaluation. Int J Pharm Res Alli Sci. 2015;4(3):114–26.

Sellappan V, Srinivas P. Formulation and evaluation of losartan potassium mucoadhesive buccal tablets. Asian J Pharm Clin Res. 2013;6(3):125–30.

Darekar SS, Khadabadi SS, Shahi SR. Formulation and evaluation of bilayer buccal tablets of sumatriptan succinate. Int J Pharm Sci. 2014;6(6):469–75.

Mandal MK. Dr. Patel DB. Formulation and evaluation of buccal tablets of rizatriptan benzoate. World J Pharm Res. 2019;8(12):1311–53.

Shojaei AH, Chang RK, Guo X, Burnside BA, Couch RA. Systemic drug delivery via the buccal mucosal route. Pharm Technol. 2001:70–81.

Ishwariya VT, Rao HO. Buccal tablets: a comprehensive review. EU J Pharm Res. 2016;3(8):252–62.

Raghavendra Rao NG, Shravani B, Srikanth RM. Overview on buccal drug delivery system. J Pharm Sci Res. 2013;5(4):80–8.

Jagadeeshwar RR. Anjum M. Hussain MA et al., A comprehensive review on buccal, drug delivery system. Am J Adv Drug Deli. 2013;1(3):300–12.

Mujoriya R, Dhamande K, Wankhede U. A Review on study of buccal drug delivery system, innovative systems. Des Eng. 2011;2(3).

Shankar G, Kumar CK, Gonugunta CS, Kumar B. V, Veerareddy PR. Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets. AAPS Pharm. Sci Technol. 2009;10(2):530–9.

Nagai T, Machida Y. Advances in drug delivery: mucosal adhesive dosage forms. Pharm Int. 1985;6:196–200.

Gilhotra RM, Ikram M, Srivastava S, Gilhotra N. A clinical perspective on mucoadhesive buccal drug delivery systems. J Biomed Res. 2014;28(2):81–97. doi: 10.7555/JBR.27.20120136.

Barar FSK. Anti-migraine drugs. In: Essentials of Pharmacotherapeutics. New Delhi: S Chand and Company Ltd. 2005:135–6.

Tripathi KD, Chapter 12; Section 3. Essentials of medical pharmacology, In: Therapy of migraine. 6th edition. New Delhi: Jaypee Brothers and Medical Publishers (P) Ltd. 2003. p. 161–72.

Goodman and Gilman’s: the pharmacological Basics of Theraputics,13th Edition.

Burch RC, Buse DC, Lipton RB. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37(4):631–49. doi: 10.1016/j.ncl.2019.06.001.

Jhee SS, Shiovitz T, Crawford AW, Cutler NR. Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: A comparative review. Clin Pharmacokinet. 2001;40(3):189–205. doi: 10.2165/00003088–200140030–00004.

Johnston MM, Rapoport AM. Triptans for the management of migraine. Drugs. 2010;70(12):1505–18.

Verma H, Verma S, Prasad SB, Singh H. Sublingual delivery of frovatriptan: an indication of potential alternative route. Int Sch Res Notices. 2014;2014:675868. doi: 10.1155/2014/675868.

Manogna K, Nagaveni P, Thyagaraju K. A review on mucoadhesive bilayer buccal tablets. Am J Pharm Tech Res. 2018;8(1):101–15. doi: 10.46624/ajptr.2018.v8.i1.007.

Shinkar DM, Shaikh TA, Saudagar RB. Design, optimization and evaluation of mucoadhesive buccal tablets of valsartan. Int J Pharm Sci Res. 2020;11(5):2093–103.

Naidu SD S D, Deepthi B S, Rao M P, Mogil R K, Rao V N. Formulation and evaluation of mucoadhesive buccal tablet of naratriptan hydrochloride. Int J Pharm Chem Res. 2015;1(1): 46–54.

Saleem MA, Pange SS, Shaikh AU, Singh VK. Development and evaluation of mucoadhesive buccal tablets of sumatriptan succinct using natural gums. Res J Pharm Technol. 2011;4(7):1140–6.

Krishna MS, John P, Syed JM. Formulation and in-vitro evaluation of mucoadhesive buccal tablets of atorvastatin calcium. Int J Drug Deliv. 2014;6(2):140–50.

Siju P. Paun J, Soniwala M, Chavda J. Design, development and evaluation of unidirectional buccal tablets of rizatriptan benzoate, Eu J Pharm Med res. 2018;5(1):223–34.

Wable AJ, Thokal SB, Mittal SS, Shirsat AE, Bhingare CL, Ingle PL. Effect of Formulation Parameters on sumatriptan succinate buccal mucoadhesive tablet: quality by design approach. J Appl Pharm Sci. 2013;4(4):103–11.

Ramani V, Sailor G, Patel M, Parmar G, Seth A. Experimental design approach for the formulation of controlled release buccal bilayer tablets of carvedilol. J Integr Health Sci. 2018;6(2):53–9. doi: 10.4103/JIHS.JIHS_19_18.

Fukuda IM, Pinto CFF, Moreira CdS, Saviano AM, Lourenço FR. Design of experiments (DoE) applied to pharmaceutical and analytical quality by design (QbD). Braz J Pharm Sci. 2018;54(spe). doi: 10.1590/s2175–97902018000001006.

Gouda R, Baishya H, Qing Z. Application of mathematical models in drug release kinetics of carbidopa and levodopa ER tablets. J Dev Drugs. 2017;6(2).

Paarakh PM, Jose PA, Setty CM, Christoper GVP. Release kinetics—concepts and applications. Int J Pharm Res Tech. 2018;8(1):12–20.

Minitab® 18 Support. (2022). Interpret the key results for Analyze Factorial Design. [online] Available at:

Minitab® 18 Support. (2022). Interpret the key results for Probability Plot. [online] Available at:

Minitab® 18 Support. (2022). Model summary table for Fit Regression Model. [online] Available at:



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