Formulation and Evaluation of Transungual Drug Delivery of Fluconazole Using Permeation Enhancers Screened by Hydration of Nail Plate

Authors

  • Arun Raj R.
  • Nithin Kurian

DOI:

https://doi.org/10.37591/(rrjops).v8i3.17

Abstract

The objective of the work was to formulate nail lacquer containing fluconazole an antifungual drug for the treatment of onychomycosis. Onychomycosis, a common fungal nail infection affects the people. Topical and ungual therapy is limited because of the poor permeation of the drug through nail plate. Film base was prepared using varying concentration of cellulose acetate and ethyl cellulose as polymers. The permeation enhancers were screened by nail plate hydration. The formulation was optimized using Box-Behnken design. Various physicochemical parameters like nonvolatile content, drying rate, gloss, smoothness to flow, % CDR for nail lacquer was analyzed out. All the above parameters showed satisfactory results and were within the prescribed limits. Optimum formula suggested by Design Expert software was formulated. The optimum batch shows % CDR was satisfactory and the release kinetics was of zero order. Zone of inhibition and drying time was in range with the standard. The accelerated stability studies showed no significant difference in the evaluation parameters. This proved that the formulated nail lacquer was stable. Antifungal nail lacquers with suitable permeation enhancers are far better for the treatment of onychomycosis than cream, gel and solutions. The high permeation rate helps to reduce the treatment period.

Keywords: Onychomycosis, fluconazole, nail lacquer, transungual drug delivery, permeation enhancers, Box-Behnken design

Cite this Article Arun Raj R, Nithin Kurian. Formulation and Evaluation of Transungual Drug Delivery of Fluconazole Using Permeation Enhancers Screened by Hydration of Nail Plate. Research & Reviews: A Journal of Pharmaceutical Science. 2016; 8(3): 32–45p. 

Downloads

Published

2017-12-16

Issue

Vol. 8 No. 3 (2017)

Section

Research Article

License

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

  • I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.
  • I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).
  • I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.
  •  I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

4. ________________

 

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.