Development and Characterization of Ion-Activated Ocular in situ Gel of Carbinoxamine Maleate

Authors

  • Arun Raj R Department of Pharmaceutical Sciences, RIMSR, Centre for Professional and Advanced Studies, Rubber board P O Kottayam 686009
  • Abhiram A

DOI:

https://doi.org/10.37591/(rrjops).v10i1.232

Abstract

Abstract
Objective: To formulate and evaluate ion activated in-situ gel of carbinoxamine maleate by hot method. Methods: Ion activated in-situ gel of carbinoxamine maleate were prepared by hot method. Optimization of carbinoxamine maleate in situ gel was performed using design expert software. Formulation and characterization of optimized batch of in situ gel were performed. Results: The pH of the formulation was found to be satisfactory. The drug content was within acceptable range. The drug release mechanism from the tablets was found to be non Fickian transport kind of diffusion. Conclusion: Optimized in situ gel was found to be clear with no apparent change in pH and good gelling capacity, drug content and in vitro drug release.
Keywords: Carbinoxamine maleate, in situ gel, ion-activated system, ocular drug delivery

Cite this Article
Arun RR, Abhiram A. Development and
Characterization of Ion Activated Ocular in
situ Gel of Carbinoxamine Maleate.
Research & Reviews: A Journal of
Pharmaceutical Science . 201 9 ; 10 1
28 35p.

Author Biography

Arun Raj R, Department of Pharmaceutical Sciences, RIMSR, Centre for Professional and Advanced Studies, Rubber board P O Kottayam 686009

Assistant Professor,  Department of Pharmaceutical Sciences, RIMSR, Centre for Professional and Advanced Studies, Rubber board P O Kottayam 686009

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Published

2019-06-01

Issue

Vol. 10 No. 1 (2019)

Section

Research Article

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